Duffy P E, Rapport M, Graf L
Neurology. 1980 Jul;30(7 Pt 1):778-82. doi: 10.1212/wnl.30.7.778.
Glial fibrillary acidic protein (GFAP), a protein that is associated with 9-nm filaments of astrocytes, was observed to be increased in the astrocytes surrounding senile plaques in patients with Alzheimer dementia and in aged subjects without dementia. A few GFAP-positive fibers were seen in the centers of plaques. These results emphasized the selectivity of senile changes; whereas some cells seemed to undergo degeneration or dysfunction, other cells--astrocytes--maintain their capacity for reaction and may increase the formation of at least one protein, GFAP.
胶质纤维酸性蛋白（GFAP）是一种与星形胶质细胞的9纳米细丝相关的蛋白质，在阿尔茨海默病痴呆患者和无痴呆的老年受试者中，老年斑周围的星形胶质细胞中观察到其含量增加。在斑块中心可见少数GFAP阳性纤维。这些结果强调了老年变化的选择性；虽然一些细胞似乎发生了退化或功能障碍，但其他细胞——星形胶质细胞——保持了它们的反应能力，并且可能增加至少一种蛋白质GFAP的形成。
