Davidson B J, Gambone J C, Lagasse L D, Castaldo T W, Hammond G L, Siiteri P K, Judd H L
J Clin Endocrinol Metab. 1981 Mar;52(3):404-8. doi: 10.1210/jcem-52-3-404.
To assess the role of biologically active estradiol in the development of endometrial cancer, 25 patients with endometrial tumors and a similar number of control subjects matched for age and body size were studied. No differences between the 2 groups were found for levels of total estradiol, sex hormone-binding globulin (SHBG), non-SHBG-bound estradiol, and absolute free estradiol. Body size correlated positively with levels of total, non-SHBG-bound, and absolute estradiol and negatively with SHBG levels. The obese postmenopausal women had higher total circulating levels and proportionally greater concentrations of free estradiol than nonobese subjects, suggesting a dual risk for the cellular action of circulating estradiol. These factors could contribute to the association of obesity and the occurrence of this tumor in susceptible women.
为评估生物活性雌二醇在子宫内膜癌发生发展中的作用，对25例子宫内膜肿瘤患者以及数量相近、年龄和体型匹配的对照者进行了研究。两组在总雌二醇、性激素结合球蛋白（SHBG）、非SHBG结合雌二醇和绝对游离雌二醇水平上未发现差异。体型与总雌二醇、非SHBG结合雌二醇和绝对雌二醇水平呈正相关，与SHBG水平呈负相关。肥胖绝经后女性的循环总水平和游离雌二醇浓度比例高于非肥胖者，提示循环雌二醇的细胞作用存在双重风险。这些因素可能导致肥胖与易感女性发生这种肿瘤之间存在关联。
