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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Brenneisen R, Fisch H U, Koelbing U, Geisshüsler S, Kalix P

Department of Phytochemistry, Faculty of Medicine, University of Berne, Switzerland.

Br J Clin Pharmacol. 1990 Dec;30(6):825-8. doi: 10.1111/j.1365-2125.1990.tb05447.x.

The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be due to the phenylalkylamine alkaloid cathinone. In order to determine the effects of this substance in humans, a single oral dose of cathinone or placebo was administered to six healthy male volunteers in a double-blind, random order crossover study. 2. Cathinone produced increases in blood pressure and in heart rate, and these changes were concomitant with the presence of cathinone in blood plasma. 3. The physical and mental changes that the subjects reported during the experiment indicated that cathinone has in humans euphorigenic and psychostimulant effects. 4. These observations support the assumption that cathinone is the constituent mainly responsible for the effects of khat, and they show that this alkaloid has also in humans amphetamine-like effects.

将巧茶树叶当作兴奋剂咀嚼在某些国家很常见，这种物质的作用据认为归因于苯烷基胺生物碱卡西酮。为了确定该物质对人体的影响，在一项双盲、随机顺序交叉研究中，给6名健康男性志愿者单次口服卡西酮或安慰剂。2. 卡西酮使血压和心率升高，这些变化与血浆中卡西酮的存在相伴。3. 受试者在实验过程中报告的身心变化表明，卡西酮对人体有欣快和精神兴奋作用。4. 这些观察结果支持了以下假设，即卡西酮是主要导致巧茶作用的成分，并且表明这种生物碱在人体中也有类似苯丙胺的作用。

Brenneisen R, Fisch H U, Koelbing U, Geisshüsler S, Kalix P

Department of Phytochemistry, Faculty of Medicine, University of Berne, Switzerland.

Br J Clin Pharmacol. 1990 Dec;30(6):825-8. doi: 10.1111/j.1365-2125.1990.tb05447.x.

The chewing of khat leaves as a stimulant is common in certain countries, and the effects of this material are supposed to be due to the phenylalkylamine alkaloid cathinone. In order to determine the effects of this substance in humans, a single oral dose of cathinone or placebo was administered to six healthy male volunteers in a double-blind, random order crossover study. 2. Cathinone produced increases in blood pressure and in heart rate, and these changes were concomitant with the presence of cathinone in blood plasma. 3. The physical and mental changes that the subjects reported during the experiment indicated that cathinone has in humans euphorigenic and psychostimulant effects. 4. These observations support the assumption that cathinone is the constituent mainly responsible for the effects of khat, and they show that this alkaloid has also in humans amphetamine-like effects.

将巧茶树叶当作兴奋剂咀嚼在某些国家很常见，这种物质的作用据认为归因于苯烷基胺生物碱卡西酮。为了确定该物质对人体的影响，在一项双盲、随机顺序交叉研究中，给6名健康男性志愿者单次口服卡西酮或安慰剂。2. 卡西酮使血压和心率升高，这些变化与血浆中卡西酮的存在相伴。3. 受试者在实验过程中报告的身心变化表明，卡西酮对人体有欣快和精神兴奋作用。4. 这些观察结果支持了以下假设，即卡西酮是主要导致巧茶作用的成分，并且表明这种生物碱在人体中也有类似苯丙胺的作用。