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相似文献

1
Hypermotility of the amphetamine type induced by a constituent of khat leaves.巧茶树叶成分诱发的苯丙胺类过度活动。
Br J Pharmacol. 1980 Jan;68(1):11-3. doi: 10.1111/j.1476-5381.1980.tb10690.x.
2
The effect of the alkaloid (-)cathinone on the motor activity in mice.生物碱（-）去甲伪麻黄碱对小鼠运动活性的影响。
Arch Int Pharmacodyn Ther. 1982 Feb;255(2):196-203.
3
Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect.卡西酮，一种来自巧茶树叶的生物碱，具有类似苯丙胺的释放效应。
Psychopharmacology (Berl). 1981;74(3):269-70. doi: 10.1007/BF00427108.
4
Khat: an amphetamine-like plant material.巧茶：一种类似安非他命的植物物质。
Bull World Health Organ. 1984;62(5):681-6.
5
Hyperthermic response to (-)-cathinone, an alkaloid of Catha edulis (khat).对阿拉伯茶（巧茶）生物碱（-）-去甲伪麻黄碱的热反应。
J Pharm Pharmacol. 1980 Sep;32(9):662-3. doi: 10.1111/j.2042-7158.1980.tb13031.x.
6
Effect of the alkaloid (-)-cathinone on the release of radioactivity from rat striatal tissue prelabelled with 3H-serotonin.
Neuropsychobiology. 1984;12(2-3):127-9. doi: 10.1159/000118124.
7
Neurochemical similarities between d,l-cathinone and d-amphetamine.消旋去甲伪麻黄碱与右旋苯丙胺之间的神经化学相似性。
Drug Alcohol Depend. 1982 Aug;9(4):279-84. doi: 10.1016/0376-8716(82)90067-9.
8
A constituent of khat leaves with amphetamine-like releasing properties.一种具有类似苯丙胺释放特性的巧茶树叶成分。
Eur J Pharmacol. 1980 Nov 21;68(2):213-5. doi: 10.1016/0014-2999(80)90326-x.
9
Recent advances in khat research.巧茶研究的最新进展。
Alcohol Alcohol. 1984;19(4):319-23.
10
Amphetamine-like effects in humans of the khat alkaloid cathinone.阿拉伯茶生物碱卡西酮对人体的苯丙胺样作用。
Br J Clin Pharmacol. 1990 Dec;30(6):825-8. doi: 10.1111/j.1365-2125.1990.tb05447.x.

引用本文的文献

1
Structure-Activity Relationship of Synthetic Cathinones: An Updated Review.合成卡西酮的构效关系：最新综述
ACS Pharmacol Transl Sci. 2024 Aug 6;7(9):2588-2603. doi: 10.1021/acsptsci.4c00299. eCollection 2024 Sep 13.
2
Natural Sympathomimetic Drugs: From Pharmacology to Toxicology.天然拟交感神经药物：从药理学到毒理学。
Biomolecules. 2022 Nov 30;12(12):1793. doi: 10.3390/biom12121793.
3
Involvement of CB2 Receptors in the Neurobehavioral Effects of (Vahl) Endl. (Khat) in Mice.大麻素受体 2 参与（Vahl）Endl. （阿拉伯茶）对小鼠神经行为的影响。
Molecules. 2019 Aug 30;24(17):3164. doi: 10.3390/molecules24173164.
4
Neuropharmacology of Synthetic Cathinones.合成卡西酮的神经药理学
Handb Exp Pharmacol. 2018;252:113-142. doi: 10.1007/164_2018_178.
5
Characterization of the Antinociceptive Mechanisms of Khat Extract () in Mice.巧茶提取物对小鼠的镇痛机制研究
Front Neurol. 2017 Mar 2;8:69. doi: 10.3389/fneur.2017.00069. eCollection 2017.
6
Khat use and appetite: an overview and comparison of amphetamine, khat and cathinone.恰特草的使用与食欲：苯丙胺、恰特草和卡西酮的概述与比较
J Ethnopharmacol. 2015 Feb 3;160:78-85. doi: 10.1016/j.jep.2014.11.002. Epub 2014 Nov 28.
7
Chemistry, pharmacology, and toxicology of khat (catha edulis forsk): a review.巧茶（Catha edulis Forssk）的化学、药理学及毒理学综述
Addict Health. 2011 Summer-Autumn;3(3-4):137-49.
8
Bath salts, mephedrone, and methylenedioxypyrovalerone as emerging illicit drugs that will need targeted therapeutic intervention.浴盐、甲麻黄碱和亚甲基二氧吡咯戊酮作为新兴的非法药物，将需要有针对性的治疗干预。
Adv Pharmacol. 2014;69:581-620. doi: 10.1016/B978-0-12-420118-7.00015-9.
9
Cathinone, an alkaloid from khat leaves with an amphetamine-like releasing effect.卡西酮，一种来自巧茶树叶的生物碱，具有类似苯丙胺的释放效应。
Psychopharmacology (Berl). 1981;74(3):269-70. doi: 10.1007/BF00427108.
10
Preference in rhesus monkeys given a choice between cocaine and d,l-cathinone.恒河猴在可卡因和消旋去甲伪麻黄碱之间做出选择时的偏好。
J Exp Anal Behav. 1984 Jan;41(1):35-43. doi: 10.1901/jeab.1984.41-i35.

本文引用的文献

1
Medical aspects of the chewing of khat leaves.巧茶树叶咀嚼的医学方面。
Bull World Health Organ. 1972;47(1):21-9.

巧茶树叶成分诱发的苯丙胺类过度活动。

Hypermotility of the amphetamine type induced by a constituent of khat leaves.

作者信息

Kalix P

出版信息

Br J Pharmacol. 1980 Jan;68(1):11-3. doi: 10.1111/j.1476-5381.1980.tb10690.x.

DOI:10.1111/j.1476-5381.1980.tb10690.x
PMID:7357134
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044110/
Abstract

Khat leaves, widely used as a stimulant in East Africa and the Arab Peninsula, contain the alkaloid, (-)-cathinone. The effects of this substance on the locomotor activity of rats were compared to those of (+)-amphetamine. Both substances were found to induce a similar degree of hypermotility. Furthermore, the effect of (-)-cathinone on the locomotor behaviour of hypophysectomized rats was analogous to that reported for (+)-amphetamine in such animals. The results support the claim that the symptoms caused by the chewing of khat are amphetamine-like.

摘要

巧茶树叶在东非和阿拉伯半岛被广泛用作兴奋剂，它含有生物碱（-）-去甲伪麻黄碱。将该物质对大鼠运动活性的影响与（+）-苯丙胺的影响进行了比较。发现这两种物质均可诱导相似程度的运动亢进。此外，（-）-去甲伪麻黄碱对垂体切除大鼠运动行为的影响与在这类动物中报道的（+）-苯丙胺的影响相似。这些结果支持了咀嚼巧茶所引起的症状类似于苯丙胺的说法。