肿瘤脱落与凝血
Tumor shedding and coagulation.
作者信息
Dvorak H F, Quay S C, Orenstein N S, Dvorak A M, Hahn P, Bitzer A M, Carvalho A C
出版信息
Science. 1981 May 22;212(4497):923-4. doi: 10.1126/science.7195067.
PMID:7195067
Abstract
Three syngeneic carcinomas from two species shed plasma membrane vesicles when cultured in vitro or grown in the ascites tumor form in vivo. Shed vesicles carry procoagulant activity that can account for the activation of the clotting system and the fibrin deposition associated with these and many other types of malignancy in animals and man.
摘要
来自两个物种的三种同基因癌在体外培养或在体内以腹水肿瘤形式生长时会释放质膜囊泡。释放的囊泡具有促凝活性，这可以解释动物和人类中这些以及许多其他类型恶性肿瘤相关的凝血系统激活和纤维蛋白沉积。
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