Küpper W, Dräger N, Mehlitz D, Zillmann U
Tropenmed Parasitol. 1981 Mar;32(1):58-60.
24 hartebeests (Alcelaphus buselaphus major), one waterbuck (Kobus defassa) and 16 kobs (Kobus kob) were immobilized during field work in Upper Volta. The use of the newly developed piperidine derivative R 33799 at weight treated dosage levels can be strongly recommended for the immobilisation of hartebeest. In this species the drug produces a sufficient deep analgesia within a reasonable short period for all handling purposes. It is safe, has a wide therapeutic index, can be used in syringes of not more than 1 ml capacity and is quickly reversed by the antidote (nalorphine hydrobromide). No fatalities occurred. The limited number of kobs immobilized did not allow final conclusions to be drawn on the compatibility of the drug for this game species unless the central nervous side effects as described can be explained better and overcome. Further investigation should be undertaken to study the reaction of kob to lower dosages of R 33799 and other combinations of this analgesic with other neuroleptics. Nalorphine hydrobromide proved to be a useful antidote in hartebeest, but less effective in kob.
在沃尔特河上游的野外工作期间，对24只转角牛羚（大转角牛羚亚种）、1只水羚和16只水羚进行了麻醉。强烈推荐使用新开发的哌啶衍生物R 33799，按体重给药剂量水平用于麻醉转角牛羚。在该物种中，该药物能在合理的短时间内产生足够深度的镇痛效果，以满足所有处理目的。它安全，治疗指数宽，可用于容量不超过1毫升的注射器，且能被解毒剂（氢溴酸烯丙吗啡）迅速逆转。未发生死亡情况。由于麻醉的水羚数量有限，除非能更好地解释并克服所述的中枢神经副作用，否则无法就该药物对这种猎物物种的兼容性得出最终结论。应进一步开展研究，以研究水羚对较低剂量的R 33799以及该镇痛药与其他安定药的其他组合的反应。氢溴酸烯丙吗啡被证明是转角牛羚的有效解毒剂，但对水羚的效果较差。
