3T3细胞中纤溶酶原激活物的调节：佛波酯肉豆蔻酸酯乙酸盐对亚细胞分布和分子量的影响。
Regulation of plasminogen activator in 3T3 cells: effect of phorbol myristate acetate on subcellular distribution and molecular weight.
作者信息
Jaken S, Black P H
出版信息
J Cell Biol. 1981 Sep;90(3):727-31. doi: 10.1083/jcb.90.3.727.
Abstract
The tumor promoter, phorbol myristate acetate (PMA), stimulates plasminogen activator production and extracellular release in confluent Swiss 3T3 cells. Coordinated with the increased extracellular release is a redistribution of the activity into plasma membrane-enriched fractions and a shift in the predominant molecular weight species from 75,000 to 49,000 daltons. The evidence suggests that PMA induces the formation of the 49,000 dalton species which is preferentially located in plasma membrane-enriched fractions.
摘要
肿瘤促进剂佛波醇肉豆蔻酸酯乙酸酯（PMA）可刺激融合的瑞士3T3细胞中纤溶酶原激活物的产生和细胞外释放。与细胞外释放增加相协调的是，活性重新分布到富含质膜的组分中，并且主要分子量种类从75,000道尔顿转变为49,000道尔顿。证据表明，PMA诱导了优先位于富含质膜组分中的49,000道尔顿种类的形成。
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