Christman J K, Copp R P, Pedrinan L, Whalen C E
Cancer Res. 1978 Nov;38(11 Pt 1):3854-60.
A phorbol ester promoting agent, 12-O-tetradecanoylphorbol-13-acetate, enhances plasminogen activator production in hamster cell lines that synthesize plasminogen activator immunologically identical with plasminogen activator of normal hamster lung cells. 12-O-Tetradecanoylphorbol-13-acetate exhibits a high degree of specificity in the type of plasminogen activator evoked, which is always of the lung form. No enhancement of plasminogen activator production was detected in hamster cell lines synthesizing plasminogen activator of different antigenic form, although in the presence of 12-O-tetradecanoylphorbol-13-acetate, cells of one such line initiated synthesis of plasminogen activator of the lung form.
佛波酯促进剂，12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯，可增强仓鼠细胞系中纤溶酶原激活物的产生，这些细胞系合成的纤溶酶原激活物在免疫学上与正常仓鼠肺细胞的纤溶酶原激活物相同。12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯在所诱发的纤溶酶原激活物类型上表现出高度特异性，其总是肺型的。在合成不同抗原形式纤溶酶原激活物的仓鼠细胞系中未检测到纤溶酶原激活物产生的增强，尽管在12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯存在的情况下，一个这样的细胞系的细胞开始合成肺型纤溶酶原激活物。
