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1
Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.培养的胚胎肌细胞表面细胞骨架框架与乙酰胆碱受体的相互作用。
J Cell Biol. 1982 Jan;92(1):231-6. doi: 10.1083/jcb.92.1.231.
2
Microtubules, microfilaments and the transport of acetylcholine receptors in embryonic myotubes.微管、微丝与胚胎肌管中乙酰胆碱受体的运输
Exp Cell Res. 1985 Aug;159(2):430-40. doi: 10.1016/s0014-4827(85)80016-1.
3
Role of the cytoskeleton in the formation, stabilization, and removal of acetylcholine receptor clusters in cultured muscle cells.细胞骨架在培养的肌肉细胞中乙酰胆碱受体簇的形成、稳定及清除过程中的作用。
J Cell Biol. 1984 Jul;99(1 Pt 1):148-54. doi: 10.1083/jcb.99.1.148.
4
Membrane-cytoskeleton associations during myogenesis deviate from traditional definitions.肌发生过程中的膜 - 细胞骨架关联偏离了传统定义。
Exp Cell Res. 1989 Jul;183(1):1-23. doi: 10.1016/0014-4827(89)90414-x.
5
A factor from neurons increases the number of acetylcholine receptor aggregates on cultured muscle cells.神经元产生的一种因子可增加培养的肌肉细胞上乙酰胆碱受体聚集体的数量。
Proc Natl Acad Sci U S A. 1978 Aug;75(8):4011-5. doi: 10.1073/pnas.75.8.4011.
6
Microtubules and the formation of acetylcholine receptor clusters in chick embryonic muscle cells.微管与鸡胚肌肉细胞中乙酰胆碱受体簇的形成
Eur J Cell Biol. 1985 Nov;39(1):173-8.
7
Tunicamycin increases desensitization of acetylcholine receptors in cultured mouse muscle cells.衣霉素可增加培养的小鼠肌肉细胞中乙酰胆碱受体的脱敏作用。
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Nonequivalence of alpha-bungarotoxin receptors and acetylcholine receptors in chick sympathetic neurons.鸡交感神经元中α-银环蛇毒素受体与乙酰胆碱受体的不等效性
Proc Natl Acad Sci U S A. 1978 Feb;75(2):1016-20. doi: 10.1073/pnas.75.2.1016.
9
Newly synthesized acetylcholine receptors are located in the Golgi apparatus.新合成的乙酰胆碱受体位于高尔基体中。
J Cell Biol. 1978 Jan;76(1):237-44. doi: 10.1083/jcb.76.1.237.
10
Proceedings: Appearance and disappearance of acetylcholine receptor during differentiation of embryonic chick skeletal muscle in vitro.论文集：体外培养的鸡胚骨骼肌分化过程中乙酰胆碱受体的出现与消失
Isr J Med Sci. 1975 Nov;11(11):1192.

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HDAC6 regulates microtubule stability and clustering of AChRs at neuromuscular junctions.组蛋白去乙酰化酶 6 调控神经肌肉接头处的微管稳定性和乙酰胆碱受体的聚集。
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The formation of complex acetylcholine receptor clusters requires MuSK kinase activity and structural information from the MuSK extracellular domain.乙酰胆碱受体复合物簇的形成需要 MuSK 激酶活性和 MuSK 细胞外结构域的结构信息。
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Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors.Src家族激酶通过蛋白质相互作用、磷酸化以及乙酰胆碱受体的细胞骨架连接在体内稳定神经肌肉突触。
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Agrin-induced phosphorylation of the acetylcholine receptor regulates cytoskeletal anchoring and clustering.聚集蛋白诱导的乙酰胆碱受体磷酸化调节细胞骨架锚定和聚集。
J Cell Biol. 2001 Apr 2;153(1):1-12. doi: 10.1083/jcb.153.1.1.
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Agrin-induced acetylcholine receptor clustering is mediated by the small guanosine triphosphatases Rac and Cdc42.聚集蛋白诱导的乙酰胆碱受体聚集由小GTP酶Rac和Cdc42介导。
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8
Role of actin in anchoring postsynaptic receptors in cultured hippocampal neurons: differential attachment of NMDA versus AMPA receptors.肌动蛋白在培养的海马神经元中锚定突触后受体的作用：N-甲基-D-天冬氨酸（NMDA）受体与α-氨基-3-羟基-5-甲基-4-异恶唑丙酸（AMPA）受体的差异附着
J Neurosci. 1998 Apr 1;18(7):2423-36. doi: 10.1523/JNEUROSCI.18-07-02423.1998.
9
Effects of antimitotic agents on secretion and detergent extractibility of adrenal nicotinic acetylcholine receptors.抗有丝分裂剂对肾上腺烟碱型乙酰胆碱受体分泌及去污剂提取性的影响。
Cell Mol Neurobiol. 1997 Oct;17(5):447-54. doi: 10.1023/a:1026350619823.
10
Spatial and temporal dissection of immediate and early events following cadherin-mediated epithelial cell adhesion.钙黏蛋白介导的上皮细胞黏附后即刻和早期事件的时空剖析。
J Cell Biol. 1993 Mar;120(5):1217-26. doi: 10.1083/jcb.120.5.1217.

本文引用的文献

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Ultrastructural characterization of surface specializations containing high-density acetylcholine receptors on embryonic chick myotubes in vivo and in vitro.体内和体外培养的胚胎期鸡肌管上含高密度乙酰胆碱受体的表面特化结构的超微结构特征
Dev Biol. 1981 Jul 30;85(2):267-86. doi: 10.1016/0012-1606(81)90259-1.
2
A factor from neurons induces partial immobilization of nonclustered acetylcholine receptors on cultured muscle cells.神经元产生的一种因子可诱导培养的肌肉细胞上未聚集的乙酰胆碱受体发生部分固定。
J Cell Biol. 1981 Feb;88(2):459-62. doi: 10.1083/jcb.88.2.459.
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Developmental reorganization of the skeletal framework and its surface lamina in fusing muscle cells.融合肌细胞中骨骼框架及其表面薄层的发育重组。
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The localization of acetylcholine receptor clusters in areas of cell-substrate contact in cultures of rat myotubes.大鼠肌管培养物中乙酰胆碱受体簇在细胞与底物接触区域的定位。
Cell. 1980 Aug;21(1):25-35. doi: 10.1016/0092-8674(80)90111-7.
5
Acetylcholine receptors. Distribution and extrajunctional density in rat diaphragm after denervation correlated with acetylcholine sensitivity.乙酰胆碱受体。去神经支配后大鼠膈肌中的分布及接头外密度与乙酰胆碱敏感性相关。
J Gen Physiol. 1972 Sep;60(3):248-62. doi: 10.1085/jgp.60.3.248.
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Cholinergic receptor molecules and cholinesterase molecules at mouse skeletal muscle junctions.小鼠骨骼肌接头处的胆碱能受体分子和胆碱酯酶分子。
Nature. 1971 Nov 26;234(5326):207-9. doi: 10.1038/234207a0.
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Selective solubilization of proteins and phospholipids from red blood cell membranes by nonionic detergents.非离子去污剂对红细胞膜中蛋白质和磷脂的选择性增溶作用。
J Supramol Struct. 1973;1(3):233-48. doi: 10.1002/jss.400010308.
8
The distribution of acetylcholine sensitivity over uninnervated and innervated muscle fibers grown in cell culture.乙酰胆碱敏感性在细胞培养中生长的无神经支配和有神经支配的肌纤维上的分布。
Dev Biol. 1973 Mar;31(1):147-62. doi: 10.1016/0012-1606(73)90326-6.
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Appearance of acetylcholine receptor in differentiating cultures of embryonic chick breast muscle.乙酰胆碱受体在鸡胚胸肌分化培养物中的出现。
J Cell Biol. 1973 Oct;59(1):241-5. doi: 10.1083/jcb.59.1.241.
10
Acetycholine receptor production and incorporation into membranes of developing muscle fibers.乙酰胆碱受体的产生及整合到发育中肌纤维的膜中。
Dev Biol. 1973 Jan;30(1):153-65. doi: 10.1016/0012-1606(73)90054-7.

培养的胚胎肌细胞表面细胞骨架框架与乙酰胆碱受体的相互作用。

Interaction of the cytoskeletal framework with acetylcholine receptor on th surface of embryonic muscle cells in culture.

作者信息

Prives J, Fulton A B, Penman S, Daniels M P, Christian C N

出版信息

J Cell Biol. 1982 Jan;92(1):231-6. doi: 10.1083/jcb.92.1.231.

DOI:10.1083/jcb.92.1.231
PMID:7199053
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2111995/
Abstract

To monitor the interaction of cell surface acetylcholine (AcCho) receptors with the cytoskeleton, cultured muscle cells were labeled with radioactive or fluorescent alpha-bungarotoxin and extracted with Triton X-100, using conditions that preserve internal structure. A significant population of the AcCho receptors is retained on the skeletal framework remaining after detergent extraction. The skeleton organization responsible for restricting AcCho receptors to a patched region may also result in their retention after detergent extraction.

摘要

为监测细胞表面乙酰胆碱（AcCho）受体与细胞骨架的相互作用，在保留内部结构的条件下，用放射性或荧光α-银环蛇毒素标记培养的肌肉细胞，并用Triton X-100进行提取。去污剂提取后，大量的AcCho受体保留在剩余的骨架结构上。负责将AcCho受体限制在一个斑块区域的骨架组织，也可能导致它们在去污剂提取后仍被保留。