Husband A J
J Immunol. 1982 Mar;128(3):1355-9.
Double Thiry-Vella loops were prepared in rats, each locally immunized with a different antigen, and the kinetics of appearance in the loops of antibody-containing cells (ACC) specific for each antigen was recorded. The results confirm, under more rigorously controlled conditions, the conclusions of previous work that the initial appearance of IgA lymphoblasts in the intestinal lamina propria occurs independently of antigen. In addition, these findings are extended by demonstrating 1) that there is no specialized site within the intestinal lamina propria for ACC to enter the tissue; 2) that in immunized intestine, specific ACC progressively accumulate around the crypt regions; and 3) that a proportion of this specific accumulation can be accounted for by ACC proliferation within the lamina propria.
在大鼠体内制备双三十维拉环，每个环局部用不同抗原免疫，并记录针对每种抗原的含抗体细胞（ACC）在环中出现的动力学。结果在更严格控制的条件下证实了先前工作的结论，即肠道固有层中IgA淋巴母细胞的最初出现独立于抗原。此外，这些发现还得到了扩展，表明：1）肠道固有层内没有ACC进入组织的特定部位；2）在免疫的肠道中，特定的ACC在隐窝区域周围逐渐积累；3）这种特定积累的一部分可以由固有层内ACC的增殖来解释。
