Currier R D, Eldridge R
Arch Neurol. 1982 Mar;39(3):140-4. doi: 10.1001/archneur.1982.00510150010003.
Fifty-one twin pairs, one or both members of each with multiple sclerosis (MS), were analyzed for extraneous events occurring prior to onset. Six patient groupings allowed comparison of events with and without the genetic factor. Comparison of monozygotic, discordant (one involved), and dizygotic discordant twins showed a difference. The affected members of the monozygotic pairs encountered prior to onset more birth anoxia, unusual infantile and childhood infections, major operations, and childbirth than did their unaffected twins, a difference not found when comparing dizygotic twins. The difference was most evident in the monozygotic discordant twins interviewed 30 years after onset of MS. If concordant (both involved) twins are analyzed by early vs late age of onset, these events occur at an older age in the late- and at younger age in the early-onset patients, suggesting that they may determine the age of onset of symptoms; they are suspected to be important in the causation of MS in genetically susceptible individuals, although the mechanism of their action is unknown.
对51对双胞胎进行了分析，每对双胞胎中至少有一人患有多发性硬化症（MS），研究其发病前发生的外部事件。六个患者分组用于比较有或没有遗传因素情况下的事件。对同卵双生、不一致（一方患病）和异卵双生不一致双胞胎的比较显示出差异。同卵双胞胎中患病的一方在发病前比未患病的双胞胎经历了更多的出生时缺氧、不寻常的婴幼儿和儿童期感染、大手术以及分娩，而异卵双胞胎比较时未发现这种差异。这种差异在MS发病30年后接受访谈的同卵双生不一致双胞胎中最为明显。如果对一致（双方都患病）的双胞胎按发病年龄早晚进行分析，这些事件在发病较晚的患者中发生时年龄较大，而在发病较早的患者中发生时年龄较小，这表明它们可能决定症状的发病年龄；尽管其作用机制尚不清楚，但怀疑它们在遗传易感个体的MS病因中起重要作用。
