Christie M J, Chesher G B
Life Sci. 1982 Apr 5;30(14):1173-7. doi: 10.1016/0024-3205(82)90659-2.
Mice which had been submitted to a chronic schedule of warm water swimming exhibited a naloxone precipitated withdrawal behaviour which was remarkably similar to that produced in mice following chronic morphine treatment. These results are consistent with the activation of endogenous opiates during swim stress in mice and present the possibility that opiate receptors are activated in a manner analogous to the repeated application of exogenous opiates, producing both tolerance and withdrawal-like behaviour.
接受温水慢性游泳训练的小鼠表现出纳洛酮诱发的戒断行为，这与慢性吗啡处理的小鼠所产生的戒断行为非常相似。这些结果与小鼠游泳应激期间内源性阿片类物质的激活相一致，并提示阿片受体可能以类似于反复应用外源性阿片类物质的方式被激活，从而产生耐受性和类似戒断的行为。
