Saito T, Sasaki O, Matsukuchi T, Iwamatsu M, Tamada R, Inokuchi K
Gan. 1980 Apr;71(2):226-30.
Polyploid carcinoma in the gastric antrum of a Beagle dog induced by N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) was sequentially studied by endoscopy and biopsy. Ulcer appeared on the angulus of the stomach at the 28th week and resulted in ulcer scar at the 42nd week. A new depression with atypical glands arose on the ulcer scar at the 69th week, developed elevated border at the 77th week, and progressed to a polyploid lesion at the 90th week. Well-differentiated adenocarcinoma in situ was found in the polyploid lesion at the 97th week. It gradually grew with nodular change of its surface. However, the carcinoma was ulcerated at the 126th week, became an elevated lesion with central depression at the 138th week, and finally regressed at the 154th week. At necropsy on the 202nd week, no carcinoma was found in the stomach.
通过内镜检查和活检对由N-甲基-N'-硝基-N-亚硝基胍（MNNG）诱导的比格犬胃窦部多倍体癌进行了连续研究。在第28周时胃角出现溃疡，并在第42周时形成溃疡瘢痕。在第69周时溃疡瘢痕上出现了伴有非典型腺体的新凹陷，在第77周时出现边界隆起，并在第90周时发展为多倍体病变。在第97周时在多倍体病变中发现了高分化原位腺癌。它逐渐生长，表面有结节状变化。然而，在第126周时癌发生溃疡，在第138周时变成中央凹陷的隆起病变，最终在第154周时消退。在第202周进行尸检时，在胃中未发现癌。
