Szentirmay Z, Ohgaki H, Maruyama K, Esumi H, Takayama S, Sugimura T
Biochemistry Division, National Cancer Center Research Institute, Tokyo.
Jpn J Cancer Res. 1990 Jan;81(1):6-9. doi: 10.1111/j.1349-7006.1990.tb02499.x.
A signet ring cell carcinoma in the gastric antrum of a Cynomolgus monkey induced by N-ethyl-N'-nitro-N-nitrosoguanidine was sequentially studied by endoscopy, biopsy, and autopsy. The carcinoma was first detected on the angulus of the stomach at the 38th month as a slightly elevated lesion. Sixty-one months later this tumor was found to be still in the "early" (intramucosal) stage. Another, independent, initial gastric cancer was also discovered. This is the first example of an induced gastric carcinoma remaining in the "early" stage during a six-year follow-up period after the initial histologic diagnosis.
对一只由N-乙基-N'-硝基-N-亚硝基胍诱导的食蟹猴胃窦印戒细胞癌，依次通过内镜检查、活检和尸检进行了研究。该癌在第38个月时首次在胃角处被检测到，表现为轻度隆起病变。61个月后，发现该肿瘤仍处于“早期”（黏膜内）阶段。还发现了另一例独立的原发性胃癌。这是首例在初始组织学诊断后的六年随访期内，诱导性胃癌仍处于“早期”阶段的病例。
