Saito T, Sasaki O, Tamada R, Iwamatasu M, Inokuchi K
Cancer. 1978 Sep;42(3):1246-54. doi: 10.1002/1097-0142(197809)42:3<1246::aid-cncr2820420333>3.0.co;2-n.
Fifteen male Beagle dogs received N-methyl-N-nitro-N-nitrosoguanidine (MNNG), 50 or 83 microgram/ml, in drinking water for 35 to 63 weeks. Broad superficial erosion and ulceration were observed in the angulus of the antrum and the anterior or posterior wall of the fundus during MNNG administration. After the discontinuation of MNNG administration, the erosions and ulcers healed rapidly, resulting in mucosal atrophy and scarring of the ulcer. In two dogs new depressions with atypical glands were observed by endoscopy and biopsy of the ulcer scars of the angulus, which became carcinomatous lesions at about the 100th week. Necropsy revealed 5 other carcinomas in the fundus of 5 additional dogs. One lesion was located in the ulcer scar and the other 4 in the areas of the mucosal atrophy. The possible relationship between carcinoma and the associated lesions was discussed.
15只雄性比格犬饮用含50或83微克/毫升N-甲基-N-硝基-N-亚硝基胍（MNNG）的水35至63周。在给予MNNG期间，胃窦角以及胃底前壁或后壁出现广泛的浅表糜烂和溃疡。停止给予MNNG后，糜烂和溃疡迅速愈合，导致黏膜萎缩和溃疡瘢痕形成。通过内镜检查和对胃窦角溃疡瘢痕进行活检，在2只犬中观察到有非典型腺体的新凹陷，这些凹陷在第100周左右变成癌性病变。尸检发现另外5只犬的胃底还有5处癌。1处病变位于溃疡瘢痕处，另外4处在黏膜萎缩区域。讨论了癌与相关病变之间的可能关系。
