Levander O A
Environ Health Perspect. 1978 Aug;25:77-80. doi: 10.1289/ehp.782577.
The experimental evidence obtained with laboratory animals which shows that the toxicities of lead, cadmium, and mercury can be increased by deficiencies of certain essential nutrients such as calcium, iron, zinc, and selenium is briefly reviewed. An idealized theoretical model which indicates the possible influence of multiple nutritional deficiencies on the toxicity of a heavy metal is presented. It is suggested that multiple marginal nutritional deficiencies may be of importance in determining the response of humans to the toxic effects of various heavy metal pollutants.
简要回顾了用实验动物获得的实验证据,这些证据表明,钙、铁、锌和硒等某些必需营养素缺乏会增加铅、镉和汞的毒性。提出了一个理想化的理论模型,该模型表明多种营养缺乏对重金属毒性可能产生的影响。有人认为,多种边缘性营养缺乏在确定人类对各种重金属污染物毒性作用的反应方面可能很重要。