Prijs V F, Eggermont J J
Hear Res. 1981 Mar;4(1):23-41. doi: 10.1016/0378-5955(81)90034-4.
Compound action potentials (AP) were recorded under various stimulus conditions in 31 guinea pigs. Stimulus attenuation, decrease of inter-stimulus interval, increase of the level of a continuous wide-band noise maker, and lowering the animal's temperature all resulted in a drop of the AP amplitude and an increase in latency. A narrow-band analysis of the compound APs makes it possible to describe these AP changes in terms of the response behaviour of small cochlear regions according to their central frequencies. The results show that intensity-dependent changes in the AP parameters can be explained on the basis of the tuning properties of the auditory nerve fibres when the effect of the rise time of the tone-burst stimulus is taken into account. Shortening of the inter-stimulus interval produces a complex interaction in terms of tone-burst frequency and the region along the cochlear partition that contributes dominantly to the AP. It is concluded that response contributions from the narrow bands with a central frequency near the tone-burst frequency show the most adaptation. The change in amplitude for narrow-band responses under increased masking is similar to that for stimulus attenuation. It seems, however, that the underlying masking mechanism is more comparable to the adaptation mechanism. Cooling of the animal did not affect the sharpness of tuning. In all four recording situations there seems to be a decrease in the amount of synchronization of single-fibre responses as reflected in the width of narrow-band action potentials.
在31只豚鼠中，于各种刺激条件下记录复合动作电位（AP）。刺激衰减、刺激间隔缩短、连续宽带噪声发生器水平增加以及动物体温降低均导致AP幅度下降和潜伏期延长。对复合AP进行窄带分析，使得根据小耳蜗区域的中心频率的反应行为来描述这些AP变化成为可能。结果表明，当考虑到短纯音刺激的上升时间的影响时，AP参数的强度依赖性变化可以基于听神经纤维的调谐特性来解释。刺激间隔缩短在短纯音频率以及沿耳蜗隔对AP起主要作用的区域方面产生复杂的相互作用。得出的结论是，中心频率接近短纯音频率的窄带的反应贡献表现出最大的适应性。在掩蔽增加的情况下窄带反应的幅度变化与刺激衰减时相似。然而，潜在的掩蔽机制似乎更类似于适应机制。动物冷却并未影响调谐的锐度。在所有四种记录情况下，如窄带动作电位的宽度所反映的，单纤维反应的同步量似乎都有所减少。
