通过高压液相色谱法从大鼠生物样品中分离并定量测定丙咪嗪和地昔帕明。
Separation and quantitative determination of imipramine and desipramine from rat biological samples by high pressure liquid chromatography.
作者信息
Bonora A, Borea P A
出版信息
Experientia. 1978 Nov 15;34(11):1486-8. doi: 10.1007/BF01932369.
PMID:720480
Abstract
Imipramine and its metabolite, desipramine, have been determined in several rat biological samples by high pressure liquid chromatography. The method allows one to detect 15 ng in column of both drugs with a lower sensitivity limit of 20 microgram1-(1).
摘要
通过高压液相色谱法已在几种大鼠生物样品中测定了丙咪嗪及其代谢物地昔帕明。该方法能够检测到柱中两种药物各15纳克，灵敏度下限为20微克/升（1）。
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