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维生素E对小鼠辐射后死亡的影响。

Effect of vitamin E on post irradiation death in mice.

作者信息

Malick M A, Roy R M, Sternberg J

出版信息

Experientia. 1978 Sep 15;34(9):1216-7. doi: 10.1007/BF01922966.

DOI:10.1007/BF01922966
PMID:720531
Abstract

The 30-day survival after exposure to 800 Rad 60Co gamma radiation has been compared for female mice maintained on vitamin E deficient, vitamin E supplemented or regular lab rations before and/or after irradiation. Pre- or post-irradiation dietary supplementation had no effect on survival; however, injection of alpha-tocopherol immediately after irradiation significantly reduced radiation lethality.

摘要

对在照射前和/或照射后维持在缺乏维生素E、补充维生素E或常规实验室日粮条件下的雌性小鼠，比较了暴露于800拉德60钴γ辐射后的30天存活率。照射前或照射后的饮食补充对存活率没有影响；然而，照射后立即注射α-生育酚可显著降低辐射致死率。

相似文献

1
Effect of vitamin E on post irradiation death in mice.维生素E对小鼠辐射后死亡的影响。
Experientia. 1978 Sep 15;34(9):1216-7. doi: 10.1007/BF01922966.
2
Modification of survival and hematopoiesis in mice by tocopherol injection following irradiation.照射后注射生育酚对小鼠存活和造血功能的影响
Strahlenther Onkol. 1986 Jun;162(6):391-9.
3
Modification of the clastogenic activity of X-ray and 6-mercaptopurine in mice by prefeeding with vitamins C and E.通过预先投喂维生素C和E对小鼠中X射线和6-巯基嘌呤的致断裂活性进行修饰。
J Nutr. 1992 Jul;122(7):1553-8. doi: 10.1093/jn/122.7.1553.
4
[Radiation-induced lipid peroxidation, a fish diet and modulation of the effects by vitamin E].[辐射诱导的脂质过氧化、鱼类饮食及维生素E对其影响的调节作用]
Radiobiologiia. 1990 Nov-Dec;30(6):808-13.
5
Evaluation of high-dose vitamin E as a radioprotective agent.大剂量维生素E作为辐射防护剂的评估。
Radiology. 1980 Sep;136(3):763-6. doi: 10.1148/radiology.136.3.7403557.
6
Correlation of increased mortality with the suppression of radiation-inducible microsomal epoxide hydrolase and glutathione S-transferase gene expression by dexamethasone: effects on vitamin C and E-induced radioprotection.地塞米松抑制辐射诱导的微粒体环氧化物水解酶和谷胱甘肽S-转移酶基因表达与死亡率增加的相关性：对维生素C和E诱导的辐射防护作用的影响。
Biochem Pharmacol. 1998 Nov 15;56(10):1295-304. doi: 10.1016/s0006-2952(98)00203-2.
7
Radioprotection of whole-body gamma-irradiation-induced alteration in some haematological parameters by cysteine, vitamin E and their combination in rats.半胱氨酸、维生素E及其组合对大鼠全身γ射线照射所致某些血液学参数改变的辐射防护作用
Strahlenther Onkol. 1991 Aug;167(8):498-501.
8
[Role of tocopheral (vitamin E) in the additionally damaging effect of post-radiation hyperoxia].生育酚（维生素E）在辐射后高氧的额外损伤作用中的角色
Radiobiologiia. 1976 Sep-Oct;16(5):773-6.
9
[Effect of the preliminary administration of dextran sulfate on the development of an acute radiation lesion].硫酸葡聚糖预处理对急性辐射损伤发展的影响
Farmakol Toksikol. 1979 Nov-Dec;42(6):647-50.
10
[Comparison of the effectiveness of oil and water solutions of alpha-tocopherol as radiation protection agent].[α-生育酚油溶液和水溶液作为辐射防护剂的有效性比较]
Fiziol Zh (1978). 1993 Mar-Jun;39(2-3):89-91.

引用本文的文献

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Vitamins and Radioprotective Effect: A Review.维生素与辐射防护作用：综述
Antioxidants (Basel). 2023 Mar 1;12(3):611. doi: 10.3390/antiox12030611.
2
Vitamin E Analogs as Radiation Response Modifiers.维生素E类似物作为辐射反应调节剂
Evid Based Complement Alternat Med. 2015;2015:741301. doi: 10.1155/2015/741301. Epub 2015 Aug 20.
3
Gamma-tocopherol-N,N-dimethylglycine ester as a potent post-irradiation mitigator against whole body X-irradiation-induced bone marrow death in mice.γ-生育酚-N,N-二甲基甘氨酸酯作为一种有效的辐射后缓解剂，可对抗全身X射线照射诱导的小鼠骨髓死亡。

本文引用的文献

1
Influence of Water-Soluble Vitamin E on Survival Time in Irradiated Mice.水溶性维生素E对受辐照小鼠存活时间的影响
Science. 1954 Jan 22;119(3082):126-7. doi: 10.1126/science.119.3082.126.
2
FREE-RADICAL LIPID PEROXIDATION DAMAGE AND ITS INHIBITION BY VITAMIN E AND SELENIUM.自由基脂质过氧化损伤及其维生素E和硒的抑制作用
Fed Proc. 1965 Jan-Feb;24:73-8.
3
Metabolic studies in atherosclerosis. I. Metabolic pathway of C14 labelled alpha-tocopherol.动脉粥样硬化的代谢研究。I. C14标记的α-生育酚的代谢途径。
J Radiat Res. 2014 Jan 1;55(1):67-74. doi: 10.1093/jrr/rrt094. Epub 2013 Aug 1.
4
Vitamin E: tocopherols and tocotrienols as potential radiation countermeasures.维生素 E：生育酚和三烯生育酚作为潜在的辐射对策。
J Radiat Res. 2013 Nov 1;54(6):973-88. doi: 10.1093/jrr/rrt048. Epub 2013 May 8.
5
Prevention and mitigation of acute radiation syndrome in mice by synthetic lipopeptide agonists of Toll-like receptor 2 (TLR2).合成脂肽 Toll 样受体 2（TLR2）激动剂预防和减轻小鼠急性辐射综合征。
PLoS One. 2012;7(3):e33044. doi: 10.1371/journal.pone.0033044. Epub 2012 Mar 27.
Can Med Assoc J. 1959 Feb 15;80(4):266-75.
4
Reduced effect of irradiation on normal and malignant cells irradiated in vivo in mice pretreated with vitamin E.维生素E预处理的小鼠体内照射对正常细胞和恶性细胞的辐射效应降低。
Br J Radiol. 1973 Jul;46(547):538-40. doi: 10.1259/0007-1285-46-547-538.
5
Effect of dietary vitamin E on the activities of the glutathione peroxidase system in rat tissues.膳食维生素E对大鼠组织中谷胱甘肽过氧化物酶系统活性的影响。
J Nutr. 1973 Apr;103(4):618-24. doi: 10.1093/jn/103.4.618.
6
The effect of dietary fatty acids and tocopherol on the radiosensitivity of mammalian erythrocytes.膳食脂肪酸和生育酚对哺乳动物红细胞放射敏感性的影响。
Radiat Res. 1973 Jan;53(1):49-64.
7
Some aspects of vitamin E in the expression of biological information.维生素E在生物信息表达中的某些方面。
Ann N Y Acad Sci. 1972 Dec 18;203:111-22. doi: 10.1111/j.1749-6632.1972.tb27863.x.
8
Analogs of alpha-tocopherol as inhibitors of cyclic-AMP and cyclic-GMP phosphodiesterases and effects of alpha-tocopherol deficiency on cyclic AMP-controlled metabolism.α-生育酚类似物作为环磷酸腺苷和环磷酸鸟苷磷酸二酯酶的抑制剂以及α-生育酚缺乏对环磷酸腺苷控制的代谢的影响
Biochim Biophys Acta. 1974 Mar 20;343(1):173-81.
9
Vitamin E protects mice against Diplococcus pneumoniae type I infection.维生素E可保护小鼠免受I型肺炎双球菌感染。
Infect Immun. 1974 Dec;10(6):1292-5. doi: 10.1128/iai.10.6.1292-1295.1974.
10
[A cytogenetic analysis of the antimutagenic action of alpha-tocopherol on spontaneous and radiation-induced chromosomal mutations].[α-生育酚对自发和辐射诱导染色体突变的抗诱变作用的细胞遗传学分析]
Genetika. 1975;10(7):12-17.