Ueda H, Nakanishi A, Ichijo M
Tohoku J Exp Med. 1980 Sep;132(1):111-6. doi: 10.1620/tjem.132.111.
Components of complement (protein concentrations of C1q, C3, C3-activator, C4, C5 and C9 and whole complement (hemolytic activity)) were measured in sera from full-term small-for-date (SFD) and appropriate-for-date (AFD) infants and their mothers. (1) Half the SFD infants showed lower C1q levels than the AFD infants. (2) SFD infants showed the same levels of C3 as AFD infants. (3) Although SFD infants showed slightly higher levels of C3-activator than AFD infants, there was no significant difference. (4) SFD infants and AFD infants showed the same level of C4. (5) With respect to C5, half the SFD infants showed lower levels than the AFD infants. (6) Levels of C9 in the SFD infants were essentially the same as those in the AFD infants. (7) The amount of protein in every complement component of an infant was smaller than that of the mother. In AFD infants, the infant-maternal ratios were 0.64 for C1q, 0.45 for C3, 0.29 for C3-activator, 0.43 for C4, 0.54 for C5 and 0.12 for C9. (8) The whole complement titers of umbilical cord sera from the AFD infants were approximately one half of those of the maternal sera. This is due to the smaller amount of complement protein itself in the infant sera. (9) The whole complement titers of umbilical cord serum agreeably correlate with gestational weeks and birth weight of the infants. (10) The whole complement titer in full-term SFD infants was lower than that in normal full-term AFD infants.
检测了足月小样儿（SFD）和适于胎龄儿（AFD）及其母亲血清中的补体成分（C1q、C3、C3激活物、C4、C5和C9的蛋白浓度以及总补体（溶血活性））。（1）一半的SFD婴儿C1q水平低于AFD婴儿。（2）SFD婴儿的C3水平与AFD婴儿相同。（3）尽管SFD婴儿的C3激活物水平略高于AFD婴儿，但差异无统计学意义。（4）SFD婴儿和AFD婴儿的C4水平相同。（5）关于C5，一半的SFD婴儿水平低于AFD婴儿。（6）SFD婴儿的C9水平与AFD婴儿基本相同。（7）婴儿每种补体成分的蛋白量均低于母亲。在AFD婴儿中，婴儿与母亲的比例分别为：C1q为0.64，C3为0.45，C3激活物为0.29，C4为0.43，C5为0.54，C9为0.12。（8）AFD婴儿脐带血清的总补体效价约为母亲血清的一半。这是由于婴儿血清中补体蛋白本身的量较少。（9）脐带血清的总补体效价与婴儿的孕周和出生体重呈良好的相关性。（10）足月SFD婴儿的总补体效价低于正常足月AFD婴儿。
