Craig P S, Rickard M D
Z Parasitenkd. 1981;64(2):169-77. doi: 10.1007/BF00930493.
Using a peroxidase micro-enzyme--linked--immunosorbent assay (ELISA) method anti-oncospheral antibodies were demonstrated in sera from four lambs after primary and challenge infections with Taenia ovis or T. hydatigena. Antibodies assayed using homologous oncospheral antigen (OA) reached a peak by 3-4 weeks after primary infection and at 1-3 weeks post-challenge infection, but waned to pre-infective, "background" levels by 8-12 weeks after each infection. Antibodies assayed against antigens in strobilar or cystic larval extracts persisted for long periods after the initial infections and exhibited different kinetics of response from those demonstrated against OA. These antibodies showed increased levels after challenge infection. Oncospheral antigens did not seem to be species specific although they appeared to elicit a stage-specific response. It is suggested that the anti-oncospheral antibody response could be associated with protective or "functional" antibody.
采用过氧化物酶微酶联免疫吸附测定（ELISA）方法，在4只羔羊经绵羊带绦虫或泡状带绦虫初次感染和攻击感染后的血清中检测到抗六钩蚴抗体。使用同源六钩蚴抗原（OA）检测的抗体在初次感染后3 - 4周以及攻击感染后1 - 3周达到峰值，但在每次感染后8 - 12周降至感染前的“背景”水平。针对节片或囊尾蚴幼虫提取物中的抗原检测的抗体在初次感染后长期存在，并且表现出与针对OA检测的抗体不同的反应动力学。这些抗体在攻击感染后水平升高。六钩蚴抗原似乎不是种特异性的，尽管它们似乎引发阶段特异性反应。有人提出，抗六钩蚴抗体反应可能与保护性或“功能性”抗体有关。
