Kjaer M
Acta Neurol Scand. 1980 Jul;62(1):1-13. doi: 10.1111/j.1600-0404.1980.tb02998.x.
Visual evoked potentials (VEPs) by checkerboard pattern-reversal stimulation were recorded in 70 subjects aged 10--69 years and in 100 patients with definite, probable or possible multiple sclerosis (MS). Longer latencies and smaller amplitudes of the major positive component were found in male subjects, in old subjects and when the amplifier's band-pass was narrowed. Subjects 10--14 years old had longer latencies and higher amplitudes than mature adults. Based on findings in the normal material, the following three criteria were used in evaluating the recordings from patients: the latency, the side difference in latencies and the ratio of amplitudes between the two sides of the major positive component with various limits for the two sexes and different age groups. The incidence of abnormal recordings was 85% for all the patients, 100% in 50 patients with definite, 70% in 50 patients with probable or possible MS, 73% in patients who had a history of spinal symptoms only, 98% if they had and 74% if they had not experienced optic neuritis. The incidence of abnormal findings increased with increasing duration of symptoms. All patients with visual acuity below 0.67 had abnormal VEPs. The high incidence of abnormal recordings confirmed the value of the test in establishing the diagnosis, and suggested that the use of different normative values for sex and age may increase the diagnostic yield without increasing the number of false positive findings.
采用棋盘格模式反转刺激记录了70名年龄在10至69岁的受试者以及100名确诊、可能或疑似患有多发性硬化症（MS）的患者的视觉诱发电位（VEP）。发现男性受试者、老年受试者以及放大器带通变窄时，主要正波成分的潜伏期延长且波幅减小。10至14岁的受试者比成年人的潜伏期更长、波幅更高。基于正常受试者的研究结果，采用以下三项标准评估患者的记录：潜伏期、潜伏期的双侧差异以及主要正波成分两侧波幅的比值，并针对不同性别和年龄组设定了不同的限值。所有患者中异常记录的发生率为85%，50名确诊患者中为100%，50名可能或疑似MS患者中为70%，仅有脊髓症状病史的患者中为73%，有视神经炎病史的患者中为98%，无视神经炎病史的患者中为74%。异常发现的发生率随症状持续时间的增加而升高。所有视力低于0.67的患者VEP均异常。异常记录的高发生率证实了该检查在诊断中的价值，并表明针对性别和年龄使用不同的正常参考值可能在不增加假阳性结果数量的情况下提高诊断率。
