Lefford M J, McGregor D D
Immunology. 1978 Apr;34(4):581-90.
Inbred rats were immunized with living BCG and lymphocytes which mediate tuberculin DTH and anti-tuberculosis immunity were found 10 days later in the draining lymph nodes, thoracic duct, blood, spleen and acute peritoneal exudates. The lymphocytes that mediated DTH incorporated 3HT in vitro, were large in size, sensitive to vinblastine but relatively resistant to irradiation, and had a short effective lifespan in syngeneic recipients. These properties characterize the cells as short-lived, nonrecirculating immunoblasts. In some experimental situations it was possible to dissociate the expression of DTH and immunity following the transfer of sensitized lymphocytes.
将近交系大鼠用活卡介苗免疫，10天后在引流淋巴结、胸导管、血液、脾脏和急性腹膜渗出物中发现介导结核菌素迟发型超敏反应（DTH）和抗结核免疫的淋巴细胞。介导DTH的淋巴细胞在体外能摄取3HT，体积较大，对长春碱敏感但对辐射相对抗性较强，并且在同基因受体中的有效寿命较短。这些特性表明这些细胞是短命的、不循环的免疫母细胞。在某些实验情况下，转移致敏淋巴细胞后有可能使DTH和免疫的表达分离。
