T细胞在介导对单核细胞增生李斯特菌的获得性抗性中的协同作用。
T-cell co-operation in the mediation of acquired resistance to Listeria monocytogenes.
作者信息
Chen-Woan M, Sajewski D H, McGregor D D
出版信息
Immunology. 1985 Sep;56(1):33-42.
Abstract
Monoclonal antibodies were used to select T-cell subsets that mediate delayed-type hypersensitivity (DTH) and acquired cellular resistance (CRI) in rats infected with Listeria monocytogenes. The mediators of DTH were identified as W3/25+ OX8- T cells. The latter comprised a subset distinct from that which could protect recipient rats against a Listeria challenge. The protective T cells had a W3/25- OX8+ phenotype. The T-cell mediators of cellular resistance to infection (TCRI) failed to augment the expression of DTH; however, the mediators of DTH (TDTH) significantly enhanced the protective capacity of TCRI. This property of TDTH correlated with the ability of the cells to promote the focal deployment of TCRI and macrophages at sites of soluble Listeria antigen injection in skin, and in peritoneal exudates induced by killed L. monocytogenes. These findings illustrate the co-operative interaction of activated T cells in acquired resistance to L. monocytogenes, and imply that DTH has a purposeful role in the host defence against infection.
摘要
使用单克隆抗体来选择介导迟发型超敏反应（DTH）和获得性细胞抗性（CRI）的T细胞亚群，这些T细胞亚群来自感染单核细胞增生李斯特菌的大鼠。DTH的介质被鉴定为W3/25 + OX8 - T细胞。后者组成了一个与能够保护受体大鼠抵御李斯特菌攻击的细胞亚群不同的亚群。保护性T细胞具有W3/25 - OX8 + 表型。细胞抗感染抗性的T细胞介质（TCRI）未能增强DTH的表达；然而，DTH的介质（TDTH）显著增强了TCRI的保护能力。TDTH的这一特性与细胞在皮肤中可溶性李斯特菌抗原注射部位以及由灭活的单核细胞增生李斯特菌诱导的腹腔渗出物中促进TCRI和巨噬细胞局部部署的能力相关。这些发现说明了活化T细胞在获得性抗单核细胞增生李斯特菌抗性中的协同相互作用，并暗示DTH在宿主抗感染防御中具有重要作用。
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