Bowden T A, Mansberger A R, Lykins L E
Am Surg. 1981 Apr;47(4):178-83.
Over an 18-year period 16 patients with pseudomembraneous enterocolitis were treated by restoration of floral homeostasis by administration of fecal enemas when standard accepted forms of therapy had failed to resolve the disease. Thirteen of the patients responded dramatically, with decreases in diarrhea, temperature, white blood cell counts, and a rapid convalesence. Of the three patients who died, two did not have the pseudomembrane at death, and one had involvement of the small bowel. No ill effects from the fecal enemas were noted. The observation of the pseudomembrane involving only the right half of the colon in a patient with a diverting transverse colostomy indicates that the disease is a contact mucositis.
在18年期间，16例伪膜性小肠结肠炎患者在标准的公认治疗方法未能治愈该病时，通过给予粪便灌肠恢复肠道菌群平衡进行治疗。13例患者反应显著，腹泻、体温、白细胞计数下降，且迅速康复。在死亡的3例患者中，2例死亡时无伪膜，1例累及小肠。未观察到粪便灌肠的不良影响。一名行横结肠造口术的患者，其伪膜仅累及结肠右半部分，这一观察结果表明该病是一种接触性粘膜炎。
