新西兰黑/白F1杂交小鼠的巨噬细胞清除功能与免疫复合物疾病
Macrophage clearance function and immune complex disease in New Zealand Black/White F1 hybrid mice.
作者信息
Morgan A G, Steward M W
出版信息
Clin Exp Immunol. 1976 Oct;26(1):133-6.
Abstract
Macrophage clearance function in NZB, NZW, NZB/W, Ajax and B10D2 new mice was assessed by measurement of the rate of clearance (KPVP) of intravenously-injected 125I-labelled polyvinylpyrrolidone (PVP). There were significant strain and age-related variations in KPVP. In particular there was a marked fall in KPVP in NZB/W mice with increasing age. This fall was most apparent in female NZB/W and preceded the age at which renal disease usually develops in these animals. We suggest that ineffective macrophage function and production of low affinity antibody contribute to the early development of immune complex glomerulonephritis in these mice.
摘要
通过测量静脉注射的125I标记的聚乙烯吡咯烷酮（PVP）的清除率（KPVP），评估了NZB、NZW、NZB/W、Ajax和B10D2品系小鼠的巨噬细胞清除功能。KPVP存在显著的品系和年龄相关差异。特别是，NZB/W小鼠的KPVP随着年龄增长显著下降。这种下降在雌性NZB/W小鼠中最为明显，且早于这些动物通常发生肾脏疾病的年龄。我们认为，巨噬细胞功能低下和低亲和力抗体的产生促成了这些小鼠免疫复合物性肾小球肾炎的早期发展。
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本文引用的文献
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