Rosendal S, Carpenter D S, Mitchell W R, Wilson M R
Can Vet J. 1981 Feb;22(2):34-5.
A strain of Haemophilus pleuropneumoniae was isolated from a pig with pleuropneumonia from a herd where this condition was frequent. A formalin inactivated culture of this isolate was used as antigen in two vaccine preparations: A and B. Vaccine A had peanut oil + arlacel 80 + tween 80 as adjuvant and vaccine B had aluminum hydroxide gel as adjuvant. Twenty pigs were vaccinated twice with vaccine A and 19 with vaccine B. Twenty additional pigs were not vaccinated. All pigs were transferred to the herd. Eleven pigs in the nonvaccinated group developed pneumonia and seven of these died within eight days after exposure. None of the vaccinated pigs had signs of pneumonia. It is concluded that the vaccines prevented the acute form of pleuropneumonia due to H. pleuropneumoniae.
从一个经常发生胸膜肺炎的猪群中，一头患有胸膜肺炎的猪身上分离出了一株胸膜肺炎放线杆菌。该分离株的福尔马林灭活培养物被用作两种疫苗制剂（A和B）的抗原。疫苗A的佐剂为花生油+司盘80+吐温80，疫苗B的佐剂为氢氧化铝凝胶。20头猪用疫苗A接种了两次，19头猪用疫苗B接种。另外20头猪未接种疫苗。所有猪都被转移到该猪群中。未接种疫苗组的11头猪发生了肺炎，其中7头在接触后8天内死亡。接种疫苗的猪均无肺炎症状。得出的结论是，这些疫苗预防了由胸膜肺炎放线杆菌引起的急性胸膜肺炎。
