Rozen P, Fireman Z, Terdiman R, Hellerstein S M, Rattan J, Gilat T
Cancer. 1981 Feb 15;47(4):827-31. doi: 10.1002/1097-0142(19810215)47:4<827::aid-cncr2820470434>3.0.co;2-y.
A selective screening program for the early detection of colorectal tumors was carried out in the Tel-Aviv area. The criteria for inclusion were based, in part, on relevant epidemiologic data which showed that European- and American-born immigrants were at the highest risk for developing this cancer, followed by Israel-born Jews. The Tel-Aviv area, because of its large elderly population of European origin, has a high incidence of colorectal cancer. Families of patients with colon cancer are known to have an increased risk for developing colon tumors. These relatives were actively searched for, and were, along with the control group, examined by Hemoccult testing and flexible sigmoidoscopy. The color tumor (cancer or adenomatous polyps) rate was 6.3% in the group with a family history of colon cancer, as contrasted to 3.8% in a smaller control group without this history. This increased yield, greater than usually found in an unselected population, emphasizes the economic value of selective screening utilizing relevant epidemiologic data and the family history.
在特拉维夫地区开展了一项用于早期检测结肠直肠肿瘤的选择性筛查项目。纳入标准部分基于相关流行病学数据，这些数据表明，出生于欧洲和美国的移民患这种癌症的风险最高，其次是在以色列出生的犹太人。由于特拉维夫地区有大量欧洲裔老年人口，该地区的结肠直肠癌发病率很高。已知结肠癌患者的家族患结肠肿瘤的风险增加。对这些亲属进行了积极搜寻，并与对照组一起通过潜血试验和乙状结肠镜检查进行了检查。有结肠癌家族史的人群中颜色肿瘤（癌症或腺瘤性息肉）发生率为6.3%，相比之下，在没有这种家族史的较小对照组中这一比例为3.8%。这种高于未经过筛选人群的检出率增加，强调了利用相关流行病学数据和家族史进行选择性筛查的经济价值。
