Syrjänen K J
Gynecol Obstet Invest. 1980;11(6):350-64. doi: 10.1159/000299856.
528 women with either a dysplastic or a neoplastic change in the squamous epithelium of the uterine cervix were histologically assessed with special emphasis on the detection of the newly discovered condylomatous lesions (flat, inverted and papillomatous). A total of 289 condylomatous (CO) lesions were found, the flat being most frequent (78.9%) followed by the inverted (14.5%) and the papillomatous ones (6.6%). The mean age (31.8 years) of the women with CO lesions was significantly lower (p less than 0.0001) than that of their non-condylomatous (N-CO) counterparts (43.0 years). The classical papillomatous condyloma was characterized as a lesion of the youngest age groups and associated with mild dysplasias, while the other two condyloma types were found in somewhat older women and frequently associated with more severe epithelial atypias (the severe dysplasias, in situ and invasive carcinomas). The possible role of human papilloma virus, the etiologic agent of the condylomas, as an agent responsible for or contributing to the development of the squamous cell carcinoma of the uterine cervix was discussed in the light of the present findings. The conclusion was drawn that this possibility should be seriously considered.
对528例子宫颈鳞状上皮发育异常或肿瘤性改变的女性进行了组织学评估，特别着重于检测新发现的湿疣样病变（扁平型、内翻型和乳头型）。共发现289例湿疣样（CO）病变，其中扁平型最为常见（78.9%），其次是内翻型（14.5%）和乳头型（6.6%）。患有CO病变的女性的平均年龄（31.8岁）显著低于未患湿疣样病变（N-CO）的女性（43.0岁）（p<0.0001）。经典的乳头型湿疣被认为是最年轻年龄组的病变，且与轻度发育异常相关，而其他两种湿疣类型多见于年龄稍大的女性，且常与更严重的上皮异型性（重度发育异常、原位癌和浸润癌）相关。根据目前的研究结果，讨论了湿疣的病原体人乳头瘤病毒作为子宫颈鳞状细胞癌的致病因素或促成因素的可能作用。得出的结论是，应认真考虑这种可能性。
