Syrjänen K J, Heinonen U M, Kauraniemi T
Acta Cytol. 1981 Jan-Feb;25(1):17-22.
Cytologic smears were obtained from 272 women shown, during a mass screening program, to have histologically proven severe dysplasia, carcinoma in situ or invasive squamous cell carcinoma of the uterine cervix. These smears were scrutinized with special attention to the detection of the cytologic pattern recently established as diagnostic of condyloma virus infection in the genital tract. The results disclosed positive cytologic findings in a considerable percentage of the smears studied, in contrast to an absolute failure to demonstrate any cytologic evidence of the presence of genital herpesvirus infection. The frequency figures of the positive findings were in accordance with the previously established frequency figures of histologically verified condylomatous lesions, thus confirming the applicability of the cytologic criteria used. The significance of the findings is discussed in the light of cervical carcinogenesis, and the conclusion is drawn that one should seriously consider the possibility that the virus behind the condylomatous lesions is the agent responsible for, or contributing to, the development of uterine cervical carcinoma.
在一项大规模筛查项目中，从272名经组织学证实患有严重发育异常、原位癌或宫颈浸润性鳞状细胞癌的女性身上获取了细胞学涂片。对这些涂片进行了仔细检查，特别关注最近确立的用于诊断生殖道尖锐湿疣病毒感染的细胞学模式的检测。结果显示，在所研究的相当一部分涂片中发现了阳性细胞学结果，相比之下，完全未能证明有任何生殖器疱疹病毒感染的细胞学证据。阳性结果的频率数据与先前确立的经组织学证实的湿疣病变的频率数据一致，从而证实了所使用的细胞学标准的适用性。根据宫颈癌的发生机制对这些发现的意义进行了讨论，并得出结论：应认真考虑湿疣病变背后的病毒是导致或促成宫颈癌发生的病原体这一可能性。
