Syrjänen K J
Neoplasma. 1981;28(4):497-509.
The present communication is a comparative survey of the histological specimens derived from the dysplastic or neoplastic lesion of the uterine cervix of 400 women comprising two age-matched series (200 women in each) collected from two Finnish hospitals. Special emphasis was placed on the detection of the newly described condylomatous lesions (flat, inverted, papillomatous) and the possible variations in their biological behavior in the two series. The biological behavior of the condylomatous lesions (the distribution into the three types, their high frequency in young women, and their relationship to different degrees of epithelial atypia) was not significantly different in the two series studied. The main difference between the series was in the frequency of the condylomatous lesions which was markedly higher (p less than 0.005) in the material made up of women in eastern Finland. The results suggest that condylomatous lesions caused by human papilloma virus (HPV) are ubiquitous and characterized by a rather constant biological behavior. The reasons behind the observed local variations in their frequency remain obscure and advocate an epidemiological study combined with virological assays to be done among the patients with precancerous lesions of the uterine cervix to gain further data on the role of HPV in human squamous cell carcinogenesis.
本报告是对400名女性子宫颈发育异常或肿瘤性病变的组织学标本进行的比较研究，这些标本来自芬兰两家医院收集的两个年龄匹配组（每组200名女性）。特别强调了新描述的湿疣样病变（扁平型、内翻型、乳头型）的检测以及这两组中其生物学行为可能存在的差异。在所研究的两组中，湿疣样病变的生物学行为（分为三种类型、在年轻女性中的高频率以及与不同程度上皮异型性的关系）并无显著差异。两组之间的主要差异在于湿疣样病变的频率，在芬兰东部女性组成的样本中明显更高（p < 0.005）。结果表明，人乳头瘤病毒（HPV）引起的湿疣样病变普遍存在，且具有相当恒定的生物学行为。观察到的其频率的局部差异背后的原因仍不清楚，这表明有必要对子宫颈癌前病变患者进行流行病学研究并结合病毒学检测，以获取关于HPV在人类鳞状细胞癌发生中作用的更多数据。
