采用气相色谱-质谱碎片分析法同时测定血浆和全血中多塞平及其主要代谢物。
Simultaneous measurement of dothiepin and its major metabolites in plasma and whole blood by gas chromatography-mass fragmentography.
作者信息
Maguire K P, Norman T R, Burrows G D, Scoggins B A
出版信息
J Chromatogr. 1981 Mar 13;222(3):399-408. doi: 10.1016/s0378-4347(00)84140-7.
PMID:7228947
Abstract
A method for the simultaneous measurement of dothiepin and two of its major metabolites, northiaden and dothiepin S-oxide in both plasma and whole blood is described. The method involves the use of gas chromatography-mass fragmentography. It is selective, sensitive (1 microgram/1) and reproducible. It has been used to analyse both plasma and blood samples following single oral doses of 75 mg dothiepin in seven volunteers.
摘要
本文描述了一种同时测定血浆和全血中多塞平及其两种主要代谢物去甲替林和多塞平S-氧化物的方法。该方法采用气相色谱-质谱碎片分析法。它具有选择性、灵敏性（1微克/升）和可重复性。已用于分析7名志愿者单次口服75毫克多塞平后的血浆和血样。
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