Sloane B F, Dunn J R, Honn K V
Science. 1981 Jun 5;212(4499):1151-3. doi: 10.1126/science.7233209.
Although lysosomal enzymes are implicated in the processes of tumor invasion and metastasis, their cellular origin within the tumor is unclear. The activity of the lysosomal proteinase cathepsin B is significantly elevated in a variant of the B16 melanoma with high metastatic potential. The cathepsin B activity is localized to the lysosomes of the tumor cells.
尽管溶酶体酶与肿瘤侵袭和转移过程有关，但其在肿瘤内的细胞来源尚不清楚。在具有高转移潜能的B16黑色素瘤变体中，溶酶体蛋白酶组织蛋白酶B的活性显著升高。组织蛋白酶B的活性定位于肿瘤细胞的溶酶体中。
