哌拉西林：体外评估。
Piperacillin: in vitro evaluation.
作者信息
Bodey G P, Le Blanc B
出版信息
Antimicrob Agents Chemother. 1978 Jul;14(1):78-87. doi: 10.1128/AAC.14.1.78.
Abstract
The in vitro activity of a new semisynthetic penicillin, piperacillin, was determined against 577 clinical isolates of gram-positive cocci and gram-negative bacilli. A concentration of 12.5 mug/ml inhibited 92% of isolates of Pseudomonas aeruginosa, 82% of Serratia marcescens, 73% of Escherichia coli, 61% of Klebsiella spp., and 42% of Enterobacter spp. Most Proteus spp. were extremely susceptible; over 85% were inhibited by 0.10 mug/ml. Piperacillin failed to inhibit the growth of gram-negative bacilli when large inocula were used. The type of media and pH had variable effects on the activity of piperacillin, depending upon the organism. Piperacillin was generally less active than PC-904 against gram-negative bacilli, but was consistently more active than carbenicillin and ticarcillin.
摘要
测定了一种新型半合成青霉素哌拉西林对577株革兰氏阳性球菌和革兰氏阴性杆菌临床分离株的体外活性。浓度为12.5μg/ml时，可抑制92%的铜绿假单胞菌分离株、82%的粘质沙雷氏菌、73%的大肠杆菌、61%的克雷伯氏菌属以及42%的肠杆菌属。大多数变形杆菌属菌株极为敏感；超过85%可被0.10μg/ml抑制。当使用大量接种物时，哌拉西林无法抑制革兰氏阴性杆菌的生长。培养基类型和pH值对哌拉西林活性的影响各不相同，具体取决于所研究的微生物。总体而言，哌拉西林对革兰氏阴性杆菌的活性低于PC - 904，但始终高于羧苄西林和替卡西林。
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本文引用的文献
1
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Nature. 1967 Jul 1;215(5096):25-30. doi: 10.1038/215025a0.
2
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Am J Med Sci. 1974 Sep;268(3):149-56. doi: 10.1097/00000441-197409000-00003.
3
Infections in cancer patients. Results with gentamicin sulfate therapy.癌症患者的感染。硫酸庆大霉素治疗的结果。
Cancer. 1972 Jun;29(6):1697-701. doi: 10.1002/1097-0142(197206)29:6<1697::aid-cncr2820290638>3.0.co;2-k.
4
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Ann Intern Med. 1976 Aug;85(2):161-4. doi: 10.7326/0003-4819-85-2-161.
5
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6
Sequential hospitalwide outbreaks of resistant Serratia and Klebsiella infections.
Arch Intern Med. 1977 May;137(5):581-4.
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