Nakai Y, Wakisaka A, Aizawa M, Itakura K, Nakai H, Ohashi A
Arthritis Rheum. 1981 May;24(5):722-5. doi: 10.1002/art.1780240516.
Sixty-three Japanese patients with rheumatoid arthritis (RA) were typed for HLA-A, -B, and -DR locus specificities. A significant association was found only with increased frequency of HLA-DR4 in the patients (71.4%) compared with controls (41.8%) (corrected P = 0.007, relative risk = 3.5). No association was found with HLA-A9 or HLA-Bw54, which are in linkage disequilibrium with HLA-DR4 in the Japanese. The association between HLA-DR4 and RA observed in these Japanese patients has also been demonstrated in the white population.
对63名日本类风湿性关节炎（RA）患者进行了HLA - A、- B和 - DR位点特异性分型。结果发现，与对照组（41.8%）相比，患者中HLA - DR4频率增加具有显著相关性（71.4%）（校正P = 0.007，相对风险 = 3.5）。在日本人中，未发现与与HLA - DR4处于连锁不平衡状态的HLA - A9或HLA - Bw54存在关联。在这些日本患者中观察到的HLA - DR4与RA之间的关联在白种人群中也得到了证实。
