在从事联苯胺衍生染料称重工作的工人尿液中寻找联苯胺及其代谢物。
Search for benzidine and its metabolites in urine of workers weighing benzidine-derived dyes.
作者信息
Meal P F, Cocker J, Wilson H K, Gilmour J M
出版信息
Br J Ind Med. 1981 May;38(2):191-3. doi: 10.1136/oem.38.2.191.
Urinary benzidine and conjugates have been used to assess the extent of occupational exposure to benzidine-based azo dyes. The aim of the present study was to investigate the presence of benzidine and its conjugates in the urine of workers exposed to benzidine-derived dyes. Urine samples were collected from 29 workers in three textile dyehouses, two tanneries, and two dyestuff quality control laboratories in West Yorkshire and Lancashire. In 200 samples, obtained over a period of 15 months and analysed by gas chromatography/mass spectrometry, no free benzidine or monoacetylbenzidine was detected. Nevertheless, after strong acid hydrolysis of urine samples taken on two separate occasions from textile dye weighers where the standard of hygiene appeared below average, trace amounts of benzidine were detected suggesting the excretion of a benzidine derived dye or a metabolite thereof.
尿中联苯胺及其结合物已被用于评估职业接触联苯胺基偶氮染料的程度。本研究的目的是调查接触联苯胺衍生染料的工人尿液中联苯胺及其结合物的存在情况。从西约克郡和兰开夏郡的三个纺织染坊、两个制革厂和两个染料质量控制实验室的29名工人中收集了尿液样本。在15个月期间采集并通过气相色谱/质谱分析的200个样本中，未检测到游离联苯胺或单乙酰联苯胺。然而，在对卫生标准似乎低于平均水平的纺织染料称重工人在两个不同时间采集的尿液样本进行强酸水解后，检测到痕量联苯胺，这表明有联苯胺衍生染料或其代谢物排出。
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