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[直接偶氮染料代谢导致致瘤性二苯胺衍生物的形成]

[Formation of blastomogenic diphenylamino derivatives as a result of the metabolism of Direct azo dyes].

作者信息

Genin V A

出版信息

Vopr Onkol. 1977;23(9):50-2.

PMID:910423
Abstract

Under study was the urine from 22 workers being in long-term contact with direct azo dyes (direct black 3, direct diazo black, direct pure blue, direct light fast KU). Benzidine was found in the urine of 8 workers and dianisidine--in 3. Consequently, there occurs metabolic decomposition of the dyes concerned to free blastomogenic agents.

摘要

对22名长期接触直接偶氮染料（直接黑3、直接重氮黑、直接纯蓝、直接耐光KU）的工人的尿液进行了研究。在8名工人的尿液中发现了联苯胺，3名工人的尿液中发现了联茴香胺。因此，相关染料会发生代谢分解，产生游离的致突变剂。

相似文献

1
[Formation of blastomogenic diphenylamino derivatives as a result of the metabolism of Direct azo dyes].[直接偶氮染料代谢导致致瘤性二苯胺衍生物的形成]
Vopr Onkol. 1977;23(9):50-2.
2
[Retrospective analysis of carcinogenic hazards of beta naphthylamine and benzidine production as a stage of an epidemiological study of tumors in workers engaged in aniline dye industry].[作为苯胺染料行业工人肿瘤流行病学研究阶段的β-萘胺和联苯胺生产致癌危害的回顾性分析]
Gig Tr Prof Zabol. 1991(7):39-41.
3
Industrial experience with 3,3'-dichlorobenzidine: an epidemiological study of a chemical manufacturing plant.
J Occup Med. 1974 May;16(5):322-35.
4
Chemical monitoring of urine from workers potentially exposed to benzidine-derived azo dyes.对可能接触联苯胺衍生偶氮染料的工人尿液进行化学监测。
Toxicol Lett. 1980 Nov;7(1):29-36. doi: 10.1016/0378-4274(80)90081-8.
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Occupational exposure to aromatic amines: benzidine and benzidine-based dyes.职业性接触芳香胺：联苯胺及以联苯胺为基础的染料。
Natl Cancer Inst Monogr. 1981 Dec(58):11-3.
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Biodegradation of benzidine based azodyes Direct red and Direct blue by the immobilized cells of Pseudomonas fluorescens D41.荧光假单胞菌D41固定化细胞对偶氮染料直接红和直接蓝的生物降解作用
Indian J Exp Biol. 2002 Oct;40(10):1131-6.
7
Metabolic reduction of benzidine azo dyes to benzidine in the rhesus monkey.恒河猴体内联苯胺偶氮染料代谢还原为联苯胺的过程。
J Natl Cancer Inst. 1975 Jul;55(1):181-2. doi: 10.1093/jnci/55.1.181.
8
Metabolism of azo dyes derived from benzidine, 3,3'-dimethyl-benzidine and 3,3'-dimethoxybenzidine to potentially carcinogenic aromatic amines by intestinal bacteria.联苯胺、3,3'-二甲基联苯胺和3,3'-二甲氧基联苯胺衍生的偶氮染料被肠道细菌代谢为潜在致癌性芳香胺。
Carcinogenesis. 1982;3(11):1255-60. doi: 10.1093/carcin/3.11.1255.
9
[Benzidine dyes and risk of bladder cancer].[联苯胺染料与膀胱癌风险]
Hinyokika Kiyo. 1989 Dec;35(12):2049-56.
10
[Blastomogenic activity of aniline dyes and the registering of carcinogens in the tissues].
Gig Tr Prof Zabol. 1978 Oct(10):22-6.

引用本文的文献

1
Biomonitoring of urinary aromatic amines and arylamine hemoglobin adducts in exposed workers and nonexposed control persons.对暴露工人和非暴露对照人员进行尿中芳香胺和芳胺血红蛋白加合物的生物监测。
Int Arch Occup Environ Health. 1995;68(1):36-43. doi: 10.1007/BF01831631.
2
Search for benzidine and its metabolites in urine of workers weighing benzidine-derived dyes.在从事联苯胺衍生染料称重工作的工人尿液中寻找联苯胺及其代谢物。
Br J Ind Med. 1981 May;38(2):191-3. doi: 10.1136/oem.38.2.191.
3
Differential serum protein binding of benzidine- and benzidine-congener based dyes and their derivatives.
基于联苯胺及其同系物的染料及其衍生物的血清蛋白结合差异
Arch Toxicol. 1985 Jun;57(2):130-5. doi: 10.1007/BF00343123.
4
Studies on the relation between bladder cancer and benzidine or its derived dyes in Shanghai.上海地区膀胱癌与联苯胺及其衍生染料关系的研究。
Br J Ind Med. 1990 Aug;47(8):544-52. doi: 10.1136/oem.47.8.544.
5
Biomonitoring of aromatic amines. III: Hemoglobin binding of benzidine and some benzidine congeners.芳香胺的生物监测。III：联苯胺及其一些同系物与血红蛋白的结合
Arch Toxicol. 1990;64(2):97-102. doi: 10.1007/BF01974393.