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恒河猴体内联苯胺偶氮染料代谢还原为联苯胺的过程。

Metabolic reduction of benzidine azo dyes to benzidine in the rhesus monkey.

作者信息

Rinde E, Troll W

出版信息

J Natl Cancer Inst. 1975 Jul;55(1):181-2. doi: 10.1093/jnci/55.1.181.

DOI:10.1093/jnci/55.1.181
PMID:808635
Abstract

Rhesus monkeys were fed azo dyes derived from benzidine (a known human bladder carcinogen). The urinary excretion of free benzidine was assayed and compared to the amount excreted when benzidine itself was fed. A substantial amount of the dye fed was converted to free benzidine. Results indicate that the simple precaution in the use of only azo dyes manufactured from noncarcinogenic aromatic amines, e.g., aniline, for all consumer products appears prudent.

摘要

给恒河猴喂食源自联苯胺(一种已知的人类膀胱致癌物)的偶氮染料。测定了游离联苯胺的尿排泄量,并与喂食联苯胺本身时的排泄量进行比较。所喂食的大量染料被转化为游离联苯胺。结果表明,对于所有消费品,仅使用由非致癌性芳香胺(如苯胺)制造的偶氮染料这一简单预防措施似乎是明智的。

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