茶碱对肾脏和大脑核苷形成的抑制作用。
Theophylline inhibition of renal and cerebral nucleoside formation.
作者信息
Jensen M H
出版信息
Br J Pharmacol. 1981 Jun;73(2):467-9. doi: 10.1111/j.1476-5381.1981.tb10444.x.
Abstract
1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5'-monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.
摘要
- 茶碱可抑制大鼠肾脏和大脑中嘌呤核苷的酶促形成，其中包括腺苷（去磷酸化的腺苷5'-单磷酸）。2. 茶碱对局部血流和神经系统电生理活动的某些药理作用可能是由于抑制了内源性腺苷的形成。
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本文引用的文献
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Adenosine 3',5'-phosphate in biological materials. I. Purification and properties of cyclic 3',5'-nucleotide phosphodiesterase and use of this enzyme to characterize adenosine 3',5'-phosphate in human urine.生物材料中的3',5'-磷酸腺苷。I. 环3',5'-核苷酸磷酸二酯酶的纯化及性质，以及用该酶鉴定人尿中的3',5'-磷酸腺苷
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Blockade of striatal neurone responses to morphine by aminophylline: evidence for adenosine mediation of opiate action.氨茶碱对纹状体神经元吗啡反应的阻断作用：腺苷介导阿片类药物作用的证据。
Br J Pharmacol. 1980 May;69(1):131-7. doi: 10.1111/j.1476-5381.1980.tb10892.x.
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Adenosine inhibition of gamma-aminobutyric acid release from slices of rat cerebral cortex.腺苷对大鼠大脑皮层切片中γ-氨基丁酸释放的抑制作用。
Br J Pharmacol. 1980 May;69(1):107-12. doi: 10.1111/j.1476-5381.1980.tb10888.x.
4
Theophylline-induced seizures in accidentally overdosed neonates.意外过量服用茶碱导致新生儿惊厥。
Pediatrics. 1980 Mar;65(3):547-9.
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The 5'-nucleotidase activity in normal human serum. Electrophoretic patterns and substrate specificity.正常人血清中的5'-核苷酸酶活性。电泳图谱和底物特异性。
Clin Chim Acta. 1980 Jun 10;104(2):221-6. doi: 10.1016/0009-8981(80)90199-0.
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Stroke. 1972 Sep-Oct;3(5):560-5. doi: 10.1161/01.str.3.5.560.
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