Perrin L H, Reynolds D, Zinkernagel R, Oldstone M B
Med Microbiol Immunol. 1978 Nov 17;166(1-4):71-9. doi: 10.1007/BF02121136.
Human peripheral blood lymphocytes (PBL) harvested after vaccination with vaccinia or measles virus showed a specific activity against virus-infected target cells. This activity peaked on day 7 and was specific for the target cells infected with the virus used for the vaccination. The cytotoxic activity was not related to HLA markers. The cells involved in the cytolytic process were lymphocytes bearing Fc receptors. In addition, the cytotoxic activity was abrogated by more than 90% by rabbit Fab'2 anti-human IgG. It is therefore likely that two subpopulations of lymphocytes are involved: an antibody-secreting cell providing specific antiviral antibody and an effector cell bearing Fc receptor (K cells). Finally, these experiments suggest that antibody-dependent cell cytotoxicity may play a major role in the recovery from virus infection in man.
用牛痘或麻疹病毒接种后采集的人外周血淋巴细胞（PBL）对病毒感染的靶细胞表现出特异性活性。这种活性在第7天达到峰值，并且对用用于接种的病毒感染的靶细胞具有特异性。细胞毒性活性与HLA标志物无关。参与溶细胞过程的细胞是带有Fc受体的淋巴细胞。此外，兔Fab'2抗人IgG可使细胞毒性活性降低90%以上。因此，可能涉及两个淋巴细胞亚群：分泌特异性抗病毒抗体的抗体分泌细胞和带有Fc受体的效应细胞（K细胞）。最后，这些实验表明抗体依赖性细胞毒性可能在人类从病毒感染中恢复的过程中起主要作用。
