Obata N, Kodama S, Hando T, Hirogami T, Takeuchi S
Nihon Sanka Fujinka Gakkai Zasshi. 1980 May;32(5):550-8.
We have studied a correlation between the histological parameters such as stromal reaction to cervical cancer and cell-mediated immune response of the regional lymph nodes designated as lymphocyte depletion, unstimulated, and lymphocyte predominance pattern which were thought to reflect the cell-mediated immune reaction to cervical cancer and the DNCB skin reaction in 84 patients. 1) Group with DNCB skin reaction negative (20 cases): Eight showed no or only the slightest trace, 7 moderate degree, and 5 marked degree of the stromal reaction. The immune response of the regional lymph nodes were 4 of lymphocyte depletion, 6 of unstimulated and 10 of lymphocyte predominance pattern. 2) Group with DNCB skin reaction positive (64 cases): This group showed 7 cases with no or only the slightest trace, 30 cases with moderate degree and 27 cases with marked degree of the stromal reaction. In this group, 6 had the regional lymph nodes of lymphocyte depletion, 10 unstimulated and 48 lymphocyte predominance pattern. 3) There was a significant correlation between the DNCB skin reaction and the degree of stromal reaction (p less than 0.05), but no correlation between the DNCB skin reaction and the regional lymph node morphology was found in this study (p greater than 0.05). 4) The discrepancy between the stromal reaction, the lymph node morphology and the DNCB skin reaction was discussed in relation to the significance of these parameters.
我们研究了84例患者中宫颈癌的组织学参数（如基质反应）与区域淋巴结的细胞介导免疫反应之间的相关性，区域淋巴结的细胞介导免疫反应分为淋巴细胞耗竭型、未刺激型和淋巴细胞优势型，这些类型被认为反映了对宫颈癌的细胞介导免疫反应以及二硝基氯苯（DNCB）皮肤反应。1）DNCB皮肤反应阴性组（20例）：8例无或仅有轻微基质反应痕迹，7例为中度，5例为重度。区域淋巴结的免疫反应为淋巴细胞耗竭型4例，未刺激型6例，淋巴细胞优势型10例。2）DNCB皮肤反应阳性组（64例）：该组7例无或仅有轻微痕迹，30例为中度，27例为重度基质反应。该组中，淋巴细胞耗竭型区域淋巴结6例，未刺激型10例，淋巴细胞优势型48例。3）DNCB皮肤反应与基质反应程度之间存在显著相关性（p小于0.05），但在本研究中未发现DNCB皮肤反应与区域淋巴结形态之间存在相关性（p大于0.05）。4）讨论了基质反应、淋巴结形态与DNCB皮肤反应之间的差异及其这些参数的意义。
