Gamache F W, Myers R A, Ducker T B, Cowley R A
Surg Neurol. 1981 Feb;15(2):85-7. doi: 10.1016/0090-3019(81)90018-5.
While reports of the beneficial effects of hyperbaric oxygen therapy in experimental use appear in the literature, there have been no reports of clinical trials with hyperbaric oxygen therapy of acute spinal cord injury. A series of treatment protocols have thus been designed for treatment of acute spinal cord injury utilizing hyperbaric oxygen. The study has been in progress for the last two years and involved more than 50 patients; results from the therapy trial in 25 patients over the last 18 months will be presented in this preliminary report. Hyperbaric oxygen therapy was generally initiated approximately 7 1/2 hours following injury. Pretreatment and posttreatment motor scores were compared with those of patients given conventional therapy for acute spinal cord injury. Under these circumstances, patients receiving hyperbaric oxygen therapy appeared to recover more quickly, although their final motor scores were about the same as those of patients receiving conventional therapy. Thus, alter the time course of recovery, perhaps without altering the final neurological outcome.
虽然文献中出现了关于高压氧疗法在实验应用中的有益效果的报道，但尚无关于急性脊髓损伤高压氧疗法临床试验的报道。因此，已经设计了一系列利用高压氧治疗急性脊髓损伤的治疗方案。这项研究在过去两年一直在进行，涉及50多名患者；本初步报告将呈现过去18个月中25名患者的治疗试验结果。高压氧疗法一般在受伤后约7个半小时开始。将治疗前和治疗后的运动评分与接受急性脊髓损伤常规治疗的患者的评分进行比较。在这种情况下，接受高压氧治疗的患者似乎恢复得更快，尽管他们最后的运动评分与接受常规治疗的患者大致相同。因此，可能改变了恢复的时间进程，也许并未改变最终的神经学结果。
