Prior P, Waterhouse J A
Br J Cancer. 1981 May;43(5):623-31. doi: 10.1038/bjc.1981.92.
Index sites of breast and cervix uteri were selected from populationbased data held at the West Midlands and Birmingham Regional Cancer Registry, and the expected numbers of second primary cancers in cervix and breast were computed (sequence analyses). In the breast series (17,756 patients) a small deficit of cervical tumours was observed (O = 16, E = 2·119, O/E = 0·76, P > 0·05), while in the cervix series (4817 patients) a small excess of breast tumours was found (O = 29, E = 23·38, O/E = 1·24, P > 0·05) over a period of 15 years.A theoretical statement of the combined risk of the 2 tumours occurring in the same individual of a general population was developed and was compared with the practical approach of summing the sequence analyses (complementary analysis). Complementary analysis indicated that there was no excess of women with the 2 primary tumours (O = 45, E = 44·57, O/E = 1·01) and that cancers of the breast and cervix uteri are not aetiologically related.
乳腺癌和子宫颈癌的索引病例来自西米德兰兹郡和伯明翰地区癌症登记处保存的基于人群的数据，并计算了子宫颈和乳腺癌中第二原发性癌症的预期数量（序列分析）。在乳腺癌系列（17756例患者）中，观察到子宫颈肿瘤略有不足（观察值O = 16，预期值E = 2.119，O/E = 0.76，P>0.05），而在子宫颈癌系列（4817例患者）中，在15年期间发现乳腺癌肿瘤略有过量（观察值O = 29，预期值E = 23.38，O/E = 1.24，P>0.05）。制定了关于普通人群中同一个体发生这两种肿瘤的综合风险的理论陈述，并将其与对序列分析求和的实际方法（补充分析）进行比较。补充分析表明，同时患有这两种原发性肿瘤的女性没有过量（观察值O = 45，预期值E = 44.57，O/E = 1.01），并且乳腺癌和子宫颈癌在病因学上没有关联。
