Samanin R, Bernasconi S, Quattrone A
Psychopharmacologia. 1976 Mar 16;46(2):219-22. doi: 10.1007/BF00421395.
Quipazine, a serotonin receptor stimulant, inhibited the response of rats to painful stimuli in two methods currently used to measure antinociception in these animals: the hot plate and tail compression test. The antinocicptive action was observed with doses ranging from 5 to 20 mg/kg i.p according to the test situation. The effect was significantly antagonized by a pretreatment with methergoline, a potent serotonin antagonist. An electrolytic lesion placed in the nucleus raphe medianus, which produced a marked decrease of serotonin in the forebrain did not, or only slightly, affected the effect of quipazine, depending on the method used to measure antinociception. It is suggested that quipazine can produce antinociceptive action in rats by interacting with a serotonergic mechanism. The action appears to be due mainly to a direct action on postsynaptic serotonin receptors, although a presynaptic component can also contribute to the effect of quipazine.
喹哌嗪是一种血清素受体兴奋剂，在目前用于测量这些动物抗伤害感受的两种方法中，即热板法和尾部压迫试验中，它抑制了大鼠对疼痛刺激的反应。根据试验情况，腹腔注射5至20毫克/千克的剂量时可观察到抗伤害感受作用。用强效血清素拮抗剂麦角新碱预处理可显著拮抗该作用。在前脑血清素显著减少的中缝正中核放置电解损伤，根据用于测量抗伤害感受的方法不同，对喹哌嗪的作用没有影响或仅有轻微影响。提示喹哌嗪可通过与血清素能机制相互作用在大鼠中产生抗伤害感受作用。该作用似乎主要是由于对突触后血清素受体的直接作用，尽管突触前成分也可能对喹哌嗪的作用有贡献。
