Multigner L, Figarella C, Sarles H
Gut. 1981 May;22(5):350-4. doi: 10.1136/gut.22.5.350.
Lactoferrin is a non-enzymatic secretory protein of human pancreas and is specifically increased in pancreatic juice of patients with chronic pancreatitis. Duodenal contents being easier to obtain than pure pancreatic juice, the possibility of using lactoferrin measurement in duodenal juice as a diagnosis test for chronic pancreatitis was explored. Forty-eight patients were studied. Duodenal juice was obtained devoid of salivary contamination by a special double lumen tube. Under these conditions lactoferrin secretion (concentration and output) is increased in patients with chronic pancreatitis. When expressed as the ratio of lactoferrin to lipase units, there was no overlap between chronic pancreatitis and other pancreatic disease or controls. The simplicity and the reproducibility of the technique on a material as readily available as duodenal juice confirms the diagnostic value of lactoferrin measurement in the assessment of patients with suspected pancreatic disease.
乳铁蛋白是一种人类胰腺的非酶分泌蛋白，在慢性胰腺炎患者的胰液中会特异性增加。十二指肠内容物比纯胰液更容易获取，因此探讨了将十二指肠液中乳铁蛋白的检测用作慢性胰腺炎诊断试验的可能性。对48名患者进行了研究。通过一种特殊的双腔管获取无唾液污染的十二指肠液。在这些条件下，慢性胰腺炎患者的乳铁蛋白分泌（浓度和排出量）会增加。当以乳铁蛋白与脂肪酶单位的比值表示时，慢性胰腺炎与其他胰腺疾病或对照组之间没有重叠。该技术在像十二指肠液这样容易获取的材料上的简便性和可重复性证实了乳铁蛋白检测在评估疑似胰腺疾病患者中的诊断价值。
