Riser E, Noone P, Thompson R E
J Hyg (Lond). 1978 Feb;80(1):43-56. doi: 10.1017/s0022172400053389.
The fluorescent antibody technique was used to investigate an epidemic of Klebsiella infection in a urological ward and to trace the probable source to a contaminated sink in the treatment room. It was also shown that cross infections by particular capsular types were very common within each ward. Certain types of Klebsiella occurred in cut flower water but could not be associated with the types infecting the patients. Antibiotic resistance patterns within one capsular type were found to vary whether the type was from different sources in one patient or from different patients in the same ward. One capsular type was observed to develop resistance to increasing numbers of antibiotics over a 3-year period. This was probably due to the acquisition of R-plasmids. There also appeared to be a relation between capsular type and the site of infection. The frequency of Klebsiella infections in the urological wards dropped significantly after up-grading the treatment room, improving catheter storage and reducing ampicillin use.
荧光抗体技术被用于调查一家泌尿外科病房的克雷伯菌感染疫情，并追踪到可能的源头是治疗室一个受污染的水槽。研究还表明，特定荚膜型的交叉感染在每个病房内都非常普遍。某些类型的克雷伯菌出现在插花水中，但与感染患者的类型无关。发现同一荚膜型内的抗生素耐药模式存在差异，无论该类型是来自同一患者的不同来源还是同一病房的不同患者。观察到一种荚膜型在3年时间里对越来越多的抗生素产生耐药性。这可能是由于获得了R质粒。荚膜型与感染部位之间似乎也存在关联。升级治疗室、改善导管储存并减少氨苄西林的使用后，泌尿外科病房克雷伯菌感染的发生率显著下降。
