Hayes H M, Milne K L, Mandell C P
Vet Rec. 1981 May 30;108(22):476-9. doi: 10.1136/vr.108.22.476.
An epidemiological survey involving 132 cats with mammary neoplasia, seen at 15 North American veterinary medical teaching hospitals, was conducted. The ratio of malignant to benign tumours was 9:1. There were 113 cases of carcinomas of all types (including two males), with adenocarcinoma being the predominant cell-type. Relative risk analysis indicated that the Siamese breed had twice the risk (P less than 0.01) of developing mammary carcinoma compared to all breeds combined. The age at diagnosis in Siamese females tended to be younger than in other breeds. Comparison of clinical and pathological features of breast cancer suggests that the cat is an appropriate surrogate for the experimental study of human breast cancer. The apparent lack of oestrogen dependency in feline breast cancer also suggests that the cat may be especially suited for evaluating therapeutic regimens for breast cancers that do not respond to hormonal manipulation.
对北美15家兽医学教学医院收治的132只患有乳腺肿瘤的猫进行了一项流行病学调查。恶性肿瘤与良性肿瘤的比例为9:1。共有113例各类癌（包括2只雄性猫），腺癌是主要的细胞类型。相对风险分析表明，与所有品种的猫加起来相比，暹罗猫品种患乳腺癌的风险是其两倍（P小于0.01）。暹罗母猫的诊断年龄往往比其他品种的猫小。对乳腺癌临床和病理特征的比较表明，猫是人类乳腺癌实验研究的合适替代对象。猫乳腺癌明显缺乏雌激素依赖性，这也表明猫可能特别适合评估对激素操纵无反应的乳腺癌的治疗方案。
