Corkey C W, Newth C J, Corey M, Levison H
Am J Obstet Gynecol. 1981 Aug 1;140(7):737-42. doi: 10.1016/0002-9378(81)90732-8.
Pregnancy in patients with cystic fibrosis is likely to become a more common occurrence as a result of improving survival rates in females with this condition. Eleven pregnancies in seven patients with cystic fibrosis are presented. Despite previous reports on the hazards of pregnancy in women with cystic fibrosis, only one pregnancy required a therapeutic abortion to preserve the health of the mother. Nine of the pregnancies occurred in five mothers who had no pancreatic insufficiency, and no significant deterioration in pulmonary function occurred during or after pregnancy. These patients who do not require pancreatic enzyme supplementation appear to represent a special subgroup within cystic fibrosis in whom not only pulmonary function but also the overall prognosis is better, and in whom pregnancy can be tolerated without undue hazard.
由于患有囊性纤维化的女性生存率提高，囊性纤维化患者怀孕可能会变得更加常见。本文介绍了7例囊性纤维化患者的11次怀孕情况。尽管之前有关于囊性纤维化女性怀孕风险的报道，但只有1次怀孕需要进行治疗性流产以保护母亲健康。9次怀孕发生在5名无胰腺功能不全的母亲身上，孕期及产后肺功能均无明显恶化。这些不需要补充胰酶的患者似乎代表了囊性纤维化中的一个特殊亚组，他们不仅肺功能较好，总体预后也较好，并且能够耐受怀孕而无过度风险。
