Gerencer M, Kastelan A, Drazancić A, Kerhin-Brkljacić V, Madjarić M
Tissue Antigens. 1978 Sep;12(3):223-7. doi: 10.1111/j.1399-0039.1978.tb01327.x.
Women with recurrent abnormal pregnancies of unknown etiology--as compared with those with recurrent abnormal pregnancies of known etiology and with normal controls--had a significantly increased frequency of antigen HLA--A9 (corr. P less than 0.01). Analysis of the frequencies in matings performed at different levels of HLA incompatibility between parents in 35 couples with recurrent abnormal pregnancies of unknown etiology revealed a high degree of wife husband compatibility of the antigens of the HLA--A locus, but not of the antigens of the HLA--B locus. These results indicate that the HLA chromosomal region may influence the reproductive efficiency and the fate of the fetus.
病因不明的复发性异常妊娠女性——与病因已知的复发性异常妊娠女性及正常对照组相比——抗原HLA - A9的频率显著增加(校正P值小于0.01)。对35对病因不明的复发性异常妊娠夫妇中父母不同HLA不相容水平下交配频率的分析显示,HLA - A位点抗原的夫妻相容性较高,但HLA - B位点抗原并非如此。这些结果表明,HLA染色体区域可能影响生殖效率和胎儿的命运。