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病因不明的复发性异常妊娠女性的HLA抗原

The HLA antigens in women with recurrent abnormal pregnancies of unknown etiology.

作者信息

Gerencer M, Kastelan A, Drazancić A, Kerhin-Brkljacić V, Madjarić M

出版信息

Tissue Antigens. 1978 Sep;12(3):223-7. doi: 10.1111/j.1399-0039.1978.tb01327.x.

DOI:10.1111/j.1399-0039.1978.tb01327.x
PMID:725906
Abstract

Women with recurrent abnormal pregnancies of unknown etiology--as compared with those with recurrent abnormal pregnancies of known etiology and with normal controls--had a significantly increased frequency of antigen HLA--A9 (corr. P less than 0.01). Analysis of the frequencies in matings performed at different levels of HLA incompatibility between parents in 35 couples with recurrent abnormal pregnancies of unknown etiology revealed a high degree of wife husband compatibility of the antigens of the HLA--A locus, but not of the antigens of the HLA--B locus. These results indicate that the HLA chromosomal region may influence the reproductive efficiency and the fate of the fetus.

摘要

病因不明的复发性异常妊娠女性——与病因已知的复发性异常妊娠女性及正常对照组相比——抗原HLA - A9的频率显著增加(校正P值小于0.01)。对35对病因不明的复发性异常妊娠夫妇中父母不同HLA不相容水平下交配频率的分析显示,HLA - A位点抗原的夫妻相容性较高,但HLA - B位点抗原并非如此。这些结果表明,HLA染色体区域可能影响生殖效率和胎儿的命运。

相似文献

1
The HLA antigens in women with recurrent abnormal pregnancies of unknown etiology.病因不明的复发性异常妊娠女性的HLA抗原
Tissue Antigens. 1978 Sep;12(3):223-7. doi: 10.1111/j.1399-0039.1978.tb01327.x.
2
HLA antigen studies in women with recurrent gestational disorders.复发性妊娠疾病女性的人类白细胞抗原抗原研究
Fertil Steril. 1979 Apr;31(4):401-4.
3
HLA-A,B compatibility in parents of offspring with neural-tube defects or couples experiencing involuntary fetal wastage.神经管缺陷后代的父母或经历自然流产的夫妇中人类白细胞抗原A、B相容性
Lancet. 1979 Apr 14;1(8120):796-9. doi: 10.1016/s0140-6736(79)91317-5.
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Histocompatibility antigens and intrauterine fetal growth retardation.组织相容性抗原与宫内胎儿生长受限
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Parental HLA compatibility, fetal wastage and neural tube defects: evidence for a T/t-like locus in humans.父母的人类白细胞抗原相容性、胎儿流失与神经管缺陷:人类中存在类似T/t基因座的证据。
Am J Hum Genet. 1984 Sep;36(5):1082-91.
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Histocompatibility in couples with recurrent spontaneous abortion and normal fertility.复发性自然流产夫妇与正常生育夫妇的组织相容性
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Genetic factors in fetal losses.胎儿丢失中的遗传因素。
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HLA and red blood group antigens in pregnancy disorders.妊娠疾病中的人类白细胞抗原和红细胞血型抗原
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引用本文的文献

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HLA allele associations in idiopathic recurrent spontaneous abortion patients from India.印度特发性复发性自然流产患者中的HLA等位基因关联
J Hum Reprod Sci. 2008 Jan;1(1):19-24. doi: 10.4103/0974-1208.39592.
2
Absence of HLA association or linkage for variations in sensitivity to the odor of androstenone.雄烯酮气味敏感性变异不存在HLA关联或连锁。
Immunogenetics. 1982;15(6):579-89. doi: 10.1007/BF00347052.
3
Parental HLA compatibility, fetal wastage and neural tube defects: evidence for a T/t-like locus in humans.父母的人类白细胞抗原相容性、胎儿流失与神经管缺陷:人类中存在类似T/t基因座的证据。
Am J Hum Genet. 1984 Sep;36(5):1082-91.
4
Decreased HLA heterogeneity in parents of children with Down syndrome.唐氏综合征患儿父母的人类白细胞抗原(HLA)异质性降低。
Am J Hum Genet. 1983 Nov;35(6):1289-96.
5
Androgenetic origin of African complete hydatidiform moles demonstrated by HLA markers.通过HLA标记物证实非洲完全性葡萄胎的雄激素起源。
Hum Genet. 1985;71(2):113-6. doi: 10.1007/BF00283364.
6
Immunology of abortion.流产的免疫学
Clin Exp Immunol. 1985 Apr;60(1):1-7.
7
Immunologic and genetic factors influencing reproduction. A review.影响生殖的免疫和遗传因素。综述。
Am J Pathol. 1979 May;95(2):465-570.