Progressive Healthcare Group, Benson, AZ 85602, USA.
J Environ Public Health. 2012;2012:312836. doi: 10.1155/2012/312836. Epub 2011 Dec 15.
A family of five and pet dog who rented a water-damaged home and developed multiple health problems. The home was analyzed for species of mold and bacteria. The diagnostics included MRI for chronic sinusitis with ENT and sinus surgery, and neurological testing for neurocognitive deficits. Bulk samples from the home, tissue from the sinuses, urine, nasal secretions, placenta, umbilical cord, and breast milk were tested for the presence of trichothecenes, aflatoxins, and Ochratoxin A. The family had the following diagnosed conditions: chronic sinusitis, neurological deficits, coughing with wheeze, nose bleeds, and fatigue among other symptoms. An infant was born with a total body flare, developed multiple Cafe-au-Lait pigmented skin spots and diagnoses with NF1 at age 2. The mycotoxins were detected in bulk samples, urine and nasal secretions, breast milk, placenta, and umbilical cord. Pseudomonas aueroginosa, Acinetobacter, Penicillium, and Aspergillus fumigatus were cultured from nasal secretions (father and daughter). RT-PCR revealed A. fumigatus DNA in sinus tissues of the daughter. The dog had 72 skin lesions (sebaceous glands and lipomas) from which trichothecenes and ochratoxin A. were detected. The health of the family is discussed in relation to the most recent published literature regarding microbial contamination and toxic by-products present in water-damaged buildings.
一个五口之家和宠物狗租了一间受潮的房子，结果出现了多种健康问题。对该房屋进行了霉菌和细菌种类分析。诊断包括耳鼻喉科慢性鼻窦炎的 MRI 和鼻窦手术，以及神经认知缺陷的神经学测试。从房屋、鼻窦组织、尿液、鼻腔分泌物、胎盘、脐带和母乳中提取大量样本，检测是否存在 trichothecenes、黄曲霉毒素和 Ochratoxin A。该家庭被诊断出患有以下疾病：慢性鼻窦炎、神经功能障碍、咳嗽伴喘息、鼻出血和疲劳等症状。一名婴儿出生时全身出现皮疹，2 岁时被诊断出患有 NF1 并出现多发性 Café-au-Lait 色素斑。在房屋的大量样本、尿液和鼻腔分泌物、母乳、胎盘和脐带中检测到了真菌毒素。从鼻腔分泌物（父亲和女儿）中培养出了铜绿假单胞菌、不动杆菌、青霉和烟曲霉。RT-PCR 显示女儿鼻窦组织中存在烟曲霉 DNA。狗身上有 72 处皮肤病变（皮脂腺和脂肪瘤），从中检测到了 trichothecenes 和 ochratoxin A。本文讨论了该家庭的健康状况，并结合了最近有关受潮房屋中微生物污染和有毒副产物的文献。
